Exploring incidence and risk factors for persistent postoperative opioid use in adult surgical patients: a systematic review protocol
|dc.contributor.author||PINHEIRO, CARLOS EDUARDO|
Objective: The objective of this review is to determine the incidence of persistent postsurgical use of opioids in adult patients and the associated risk factors.
Introduction: Surgery has been identified as an independent risk factor for unwarranted chronic opioid use, contributing to opioid-related harm in the community. Persistent opioid use after surgery is associated with morbidity and mortality from opioid-related adverse events, indicating a significant yet mitigable public health concern. There is substantial variation in the reported incidence and risk factors for postoperative opioid use, which require evaluation for future evidence-based risk-reduction strategies.
Inclusion criteria: This review will include studies investigating the persistent use of opioids after 90 postoperative days in adult (≥18 y) patients undergoing surgery of any type, including patients with cancer pain. Selected evidence must report on opioid use prior to surgery. Analytical and descriptive observational studies, and experimental and quasi-experimental studies, published in the previous decade will be eligible for inclusion.
Methods: The proposed study methods follow the JBI methodology for systematic reviews of prevalence and incidence. A systematic search will be conducted in PubMed, Embase, CINAHL, Cochrane Central, and Web of Science, and a search of gray literature will include Google Scholar and ClinicalTrials.gov. Study selection, critical appraisal, and data extraction will be performed by 2 independent reviewers aided by the relevant JBI systematic review tools. We aim to produce a narrative synthesis of results and conduct a meta-analysis where feasible, in addition to subgroup analyses of suitable populations. The results are intended to promote safe, evidence-based postoperative opioid prescribing when considering risk factors for persistent postoperative opioid use.
Systematic review registration number: PROSPERO CRD42022320691
|dc.publisher||Ovid Technologies (Wolters Kluwer Health)|
|dc.subject||Practice Patterns, Physicians'|
|dc.subject||Systematic Reviews as Topic|
|dc.subject||Meta-Analysis as Topic|
|dc.subject||Review Literature as Topic|
|dc.title||Exploring incidence and risk factors for persistent postoperative opioid use in adult surgical patients: a systematic review protocol|
|plymouth.journal||JBI Evidence Synthesis|
|plymouth.organisational-group|||Plymouth|Faculty of Health|
|plymouth.organisational-group|||Plymouth|Faculty of Health|School of Nursing and Midwifery|
|plymouth.organisational-group|||Plymouth|Research Groups|Institute of Health and Community|
|plymouth.organisational-group|||Plymouth|REF 2021 Researchers by UoA|
|plymouth.organisational-group|||Plymouth|Users by role|
|plymouth.organisational-group|||Plymouth|Users by role|Academics|
|plymouth.organisational-group|||Plymouth|REF 2021 Researchers by UoA|UoA01 Clinical Medicine|
|plymouth.organisational-group|||Plymouth|REF 2021 Researchers by UoA|UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy|
|plymouth.organisational-group|||Plymouth|Faculty of Health|Peninsula Medical School|
|plymouth.organisational-group|||Plymouth|Research Groups|Plymouth Institute of Health and Care Research (PIHR)|