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dc.contributor.authorGriffiths, H
dc.contributor.authorPINHEIRO, CARLOS EDUARDO
dc.contributor.authorMartin, Daniel

Objective: The objective of this review is to determine the incidence of persistent postsurgical use of opioids in adult patients and the associated risk factors.

Introduction: Surgery has been identified as an independent risk factor for unwarranted chronic opioid use, contributing to opioid-related harm in the community. Persistent opioid use after surgery is associated with morbidity and mortality from opioid-related adverse events, indicating a significant yet mitigable public health concern. There is substantial variation in the reported incidence and risk factors for postoperative opioid use, which require evaluation for future evidence-based risk-reduction strategies.

Inclusion criteria: This review will include studies investigating the persistent use of opioids after 90 postoperative days in adult (≥18 y) patients undergoing surgery of any type, including patients with cancer pain. Selected evidence must report on opioid use prior to surgery. Analytical and descriptive observational studies, and experimental and quasi-experimental studies, published in the previous decade will be eligible for inclusion.

Methods: The proposed study methods follow the JBI methodology for systematic reviews of prevalence and incidence. A systematic search will be conducted in PubMed, Embase, CINAHL, Cochrane Central, and Web of Science, and a search of gray literature will include Google Scholar and Study selection, critical appraisal, and data extraction will be performed by 2 independent reviewers aided by the relevant JBI systematic review tools. We aim to produce a narrative synthesis of results and conduct a meta-analysis where feasible, in addition to subgroup analyses of suitable populations. The results are intended to promote safe, evidence-based postoperative opioid prescribing when considering risk factors for persistent postoperative opioid use.

Systematic review registration number: PROSPERO CRD42022320691

dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.subjectAnalgesics, Opioid
dc.subjectPractice Patterns, Physicians'
dc.subjectSystematic Reviews as Topic
dc.subjectRisk Factors
dc.subjectMeta-Analysis as Topic
dc.subjectReview Literature as Topic
dc.titleExploring incidence and risk factors for persistent postoperative opioid use in adult surgical patients: a systematic review protocol
dc.typeJournal Article
plymouth.publication-statusPublished online
plymouth.journalJBI Evidence Synthesis
plymouth.organisational-group|Plymouth|Research Groups
plymouth.organisational-group|Plymouth|Faculty of Health
plymouth.organisational-group|Plymouth|Faculty of Health|School of Nursing and Midwifery
plymouth.organisational-group|Plymouth|Research Groups|Institute of Health and Community
plymouth.organisational-group|Plymouth|REF 2021 Researchers by UoA
plymouth.organisational-group|Plymouth|Users by role
plymouth.organisational-group|Plymouth|Users by role|Academics
plymouth.organisational-group|Plymouth|REF 2021 Researchers by UoA|UoA01 Clinical Medicine
plymouth.organisational-group|Plymouth|REF 2021 Researchers by UoA|UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group|Plymouth|Faculty of Health|Peninsula Medical School
plymouth.organisational-group|Plymouth|Research Groups|Plymouth Institute of Health and Care Research (PIHR)
dc.publisher.placeUnited States

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