THE STRUCTURAL AND PHYSICAL PROPERTIES OF CRYSTALLINE ANTIBIOTIC MATERIALS
Abstract
Effectiveness in biological chemical environments virtually defines the term 'drug' when applied to any attempt to modify that environment by the introduction of an influence in terms of a specific compound or group of compounds. Interest in the configuration of the molecules involved in such modifications led to the X-ray structure determinations, discussed in the thesis, of the following three compounds: (i) 7-chloro-2-methyl-5-phenyl-3-propyl [2,3-b]-imidazolyl quinoline. Derived from the psychoactive drug Librium, it was thought to conform to the structure, containing the highly strained 4-membered monocyclic azete system (Shenoy, a thesis submitted for the degree of Doctor of Philosophy, University of London, 1975), and suggested as one of the first examples of possible stable 4-membered azacyclobutadiene rings. (ii) The methyl ester of 5,5-dimethyl-2-(2-phenoxymethyl-5-oxo-1,3-oxazolin-4-ylidene)-1,3-thiazolidine-4-carboxylic acid.
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