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dc.contributor.authorMa, R
dc.contributor.authorYan, M
dc.contributor.authorHan, P
dc.contributor.authorWang, T
dc.contributor.authorLi, B
dc.contributor.authorZhou, S
dc.contributor.authorZheng, T
dc.contributor.authorHu, Y
dc.contributor.authorBorthwick, AGL
dc.contributor.authorZheng, C
dc.contributor.authorNi, J
dc.date.accessioned2023-01-30T15:16:08Z
dc.date.issued2022-11-29
dc.identifier.issn2041-1723
dc.identifier.issn2041-1723
dc.identifier.other7354
dc.identifier.urihttp://hdl.handle.net/10026.1/20217
dc.description.abstract

<jats:title>Abstract</jats:title><jats:p>More than two billion people worldwide have suffered thyroid disorders from either iodine deficiency or excess. By creating the national map of groundwater iodine throughout China, we reveal the spatial responses of diverse health risks to iodine in continental groundwater. Greater non-carcinogenic risks relevant to lower iodine more likely occur in the areas of higher altitude, while those associated with high groundwater iodine are concentrated in the areas suffered from transgressions enhanced by land over-use and intensive anthropogenic overexploitation. The potential roles of groundwater iodine species are also explored: iodide might be associated with subclinical hypothyroidism particularly in higher iodine regions, whereas iodate impacts on thyroid risks in presence of universal salt iodization exhibit high uncertainties in lower iodine regions. This implies that accurate iodine supply depending on spatial heterogeneity and dietary iodine structure optimization are highly needed to mitigate thyroid risks in iodine-deficient and -excess areas globally.</jats:p>

dc.format.extent7354-
dc.format.mediumElectronic
dc.languageen
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.subjectHumans
dc.subjectIodides
dc.subjectIodine
dc.subjectGroundwater
dc.subjectThyroid Gland
dc.subjectSodium Chloride, Dietary
dc.titleDeficiency and excess of groundwater iodine and their health associations
dc.typejournal-article
dc.typeJournal Article
dc.typeResearch Support, Non-U.S. Gov't
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36446773
plymouth.issue1
plymouth.volume13
plymouth.publisher-urlhttp://dx.doi.org/10.1038/s41467-022-35042-6
plymouth.publication-statusPublished online
plymouth.journalNature Communications
dc.identifier.doi10.1038/s41467-022-35042-6
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Engineering, Computing and Mathematics
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeEngland
dcterms.dateAccepted2022-11-16
dc.rights.embargodate2023-1-31
dc.identifier.eissn2041-1723
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1038/s41467-022-35042-6
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2022-11-29
rioxxterms.typeJournal Article/Review


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