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dc.contributor.authorTurk, A
dc.contributor.authorWong, G
dc.contributor.authorMahtani, KR
dc.contributor.authorMaden, M
dc.contributor.authorHill, R
dc.contributor.authorRanson, E
dc.contributor.authorWallace, E
dc.contributor.authorKrska, J
dc.contributor.authorMangin, D
dc.contributor.authorByng, Richard
dc.contributor.authorLasserson, D
dc.contributor.authorReeve, J
dc.date.accessioned2022-11-02T11:51:08Z
dc.date.issued2022-08-31
dc.identifier.issn1741-7015
dc.identifier.issn1741-7015
dc.identifier.other297
dc.identifier.urihttp://hdl.handle.net/10026.1/19825
dc.description.abstract

<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>Tackling problematic polypharmacy requires tailoring the use of medicines to individual circumstances and may involve the process of deprescribing. Deprescribing can cause anxiety and concern for clinicians and patients. Tailoring medication decisions often entails beyond protocol decision-making, a complex process involving emotional and cognitive work for healthcare professionals and patients. We undertook realist review to highlight and understand the interactions between different factors involved in deprescribing and to develop a final programme theory that identifies and explains components of good practice that support a person-centred approach to deprescribing in older patients with multimorbidity and polypharmacy.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>The realist approach involves identifying underlying causal mechanisms and exploring how, and under what conditions they work. We conducted a search of electronic databases which were supplemented by citation checking and consultation with stakeholders to identify other key documents. The review followed the key steps outlined by Pawson et al. and followed the RAMESES standards for realist syntheses.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>We included 119 included documents from which data were extracted to produce context-mechanism-outcome configurations (CMOCs) and a final programme theory. Our programme theory recognises that deprescribing is a complex intervention influenced by a multitude of factors. The components of our final programme theory include the following: a supportive infrastructure that provides clear guidance around professional responsibilities and that enables multidisciplinary working and continuity of care, consistent access to high-quality relevant patient contextual data, the need to support the creation of a shared explanation and understanding of the meaning and purpose of medicines and a trial and learn approach that provides space for monitoring and continuity. These components may support the development of trust which may be key to managing the uncertainty and in turn optimise outcomes. These components are summarised in the novel DExTruS framework.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Our findings recognise the complex interpretive practice and decision-making involved in medication management and identify key components needed to support best practice. Our findings have implications for how we design medication review consultations, professional training and for patient records/data management. Our review also highlights the role that trust plays both as a central element of tailored prescribing and a potential outcome of good practice in this area.</jats:p> </jats:sec>

dc.format.extent297-
dc.format.mediumElectronic
dc.languageen
dc.language.isoeng
dc.publisherBioMed Central
dc.subjectRealist review
dc.subjectEvidence synthesis
dc.subjectDeprescribing
dc.subjectPolypharmacy
dc.subjectPerson-centred care
dc.titleOptimising a person-centred approach to stopping medicines in older people with multimorbidity and polypharmacy using the DExTruS framework: a realist review
dc.typejournal-article
dc.typeJournal Article
dc.typeReview
dc.typeResearch Support, Non-U.S. Gov't
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000847686200002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue1
plymouth.volume20
plymouth.publication-statusPublished online
plymouth.journalBMC Medicine
dc.identifier.doi10.1186/s12916-022-02475-1
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/FoH - Community and Primary Care
plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CCT&PS
plymouth.organisational-group/Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR)
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeEngland
dcterms.dateAccepted2022-07-12
dc.rights.embargodate2022-11-3
dc.identifier.eissn1741-7015
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1186/s12916-022-02475-1
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2022-08-31
rioxxterms.typeJournal Article/Review


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