Metabolomics Profiling of Vitamin D Status in Relation to Dyslipidemia
dc.contributor.author | Mousa, H | |
dc.contributor.author | Elrayess, MA | |
dc.contributor.author | Diboun, I | |
dc.contributor.author | Jackson, SK | |
dc.contributor.author | Zughaier, SM | |
dc.date.accessioned | 2022-10-31T13:29:49Z | |
dc.date.issued | 2022-08-22 | |
dc.identifier.issn | 2218-1989 | |
dc.identifier.issn | 2218-1989 | |
dc.identifier.other | 771 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/19796 | |
dc.description.abstract |
<jats:p>Vitamin D deficiency is a global disorder associated with several chronic illnesses including dyslipidemia and metabolic syndrome. The impact of this association with both dyslipidemia and vitamin D deficiency on metabolomics profile is not yet fully understood. This study analyses the metabolomics and lipidomic signatures in relation to vitamin D status and dyslipidemia. Metabolomics data were collected from Qatar Biobank database and categorized into four groups based on vitamin D and dyslipidemia status. Metabolomics multivariate analysis was performed using the orthogonal partial least square discriminate analysis (OPLS-DA) whilst linear models were used to assess the per-metabolite association with each of the four dyslipidemia/vitamin D combination groups. Our results indicate a high prevalence of vitamin D deficiency among the younger age group, while dyslipidemia was more prominent in the older group. A significant alteration of metabolomics profile was observed among the dyslipidemic and vitamin D deficient individuals in comparison with control groups. These modifications reflected changes in some key pathways including ceramides, diacylglycerols, hemosylceramides, lysophospholipids, phosphatidylcholines, phosphatidylethanol amines, and sphingomyelins. Vitamin D deficiency and dyslipidemia have a deep impact on sphingomyelins profile. The modifications were noted at the level of ceramides and are likely to propagate through downstream pathways.</jats:p> | |
dc.format.extent | 771-771 | |
dc.format.medium | Electronic | |
dc.language | en | |
dc.language.iso | eng | |
dc.publisher | MDPI | |
dc.subject | vitamin D | |
dc.subject | 25-hydroxyvitamin D | |
dc.subject | dyslipidemia | |
dc.subject | metabolomics | |
dc.subject | lipidomics | |
dc.title | Metabolomics Profiling of Vitamin D Status in Relation to Dyslipidemia | |
dc.type | journal-article | |
dc.type | Journal Article | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000845500700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 8 | |
plymouth.volume | 12 | |
plymouth.publication-status | Published online | |
plymouth.journal | Metabolites | |
dc.identifier.doi | 10.3390/metabo12080771 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/School of Biomedical Sciences | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | Switzerland | |
dcterms.dateAccepted | 2022-08-11 | |
dc.rights.embargodate | 2022-11-1 | |
dc.identifier.eissn | 2218-1989 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.3390/metabo12080771 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2022-08-22 | |
rioxxterms.type | Journal Article/Review |