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dc.contributor.authorMousa, H
dc.contributor.authorElrayess, MA
dc.contributor.authorDiboun, I
dc.contributor.authorJackson, SK
dc.contributor.authorZughaier, SM
dc.date.accessioned2022-10-31T13:29:49Z
dc.date.issued2022-08-22
dc.identifier.issn2218-1989
dc.identifier.issn2218-1989
dc.identifier.other771
dc.identifier.urihttp://hdl.handle.net/10026.1/19796
dc.description.abstract

<jats:p>Vitamin D deficiency is a global disorder associated with several chronic illnesses including dyslipidemia and metabolic syndrome. The impact of this association with both dyslipidemia and vitamin D deficiency on metabolomics profile is not yet fully understood. This study analyses the metabolomics and lipidomic signatures in relation to vitamin D status and dyslipidemia. Metabolomics data were collected from Qatar Biobank database and categorized into four groups based on vitamin D and dyslipidemia status. Metabolomics multivariate analysis was performed using the orthogonal partial least square discriminate analysis (OPLS-DA) whilst linear models were used to assess the per-metabolite association with each of the four dyslipidemia/vitamin D combination groups. Our results indicate a high prevalence of vitamin D deficiency among the younger age group, while dyslipidemia was more prominent in the older group. A significant alteration of metabolomics profile was observed among the dyslipidemic and vitamin D deficient individuals in comparison with control groups. These modifications reflected changes in some key pathways including ceramides, diacylglycerols, hemosylceramides, lysophospholipids, phosphatidylcholines, phosphatidylethanol amines, and sphingomyelins. Vitamin D deficiency and dyslipidemia have a deep impact on sphingomyelins profile. The modifications were noted at the level of ceramides and are likely to propagate through downstream pathways.</jats:p>

dc.format.extent771-771
dc.format.mediumElectronic
dc.languageen
dc.language.isoeng
dc.publisherMDPI
dc.subjectvitamin D
dc.subject25-hydroxyvitamin D
dc.subjectdyslipidemia
dc.subjectmetabolomics
dc.subjectlipidomics
dc.titleMetabolomics Profiling of Vitamin D Status in Relation to Dyslipidemia
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/36005643
plymouth.issue8
plymouth.volume12
plymouth.publisher-urlhttp://dx.doi.org/10.3390/metabo12080771
plymouth.publication-statusPublished online
plymouth.journalMetabolites
dc.identifier.doi10.3390/metabo12080771
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Biomedical Sciences
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
plymouth.organisational-group/Plymouth/Users by role/Researchers in ResearchFish submission
dc.publisher.placeSwitzerland
dcterms.dateAccepted2022-08-11
dc.rights.embargodate2022-11-1
dc.identifier.eissn2218-1989
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.3390/metabo12080771
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2022-08-22
rioxxterms.typeJournal Article/Review


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