Possible Regulation of Toll-Like Receptor 4 By Lysine Acetylation Through LPCAT2 Activity in RAW264.7 Cells.
dc.contributor.author | Poloamina, VI | |
dc.contributor.author | Abate, W | |
dc.contributor.author | Fejer, Gyorgy | |
dc.contributor.author | Jackson, SK | |
dc.date.accessioned | 2022-07-22T12:33:36Z | |
dc.date.issued | 2022-07-15 | |
dc.identifier.issn | 0144-8463 | |
dc.identifier.issn | 1573-4935 | |
dc.identifier.other | ARTN BSR20220251 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/19433 | |
dc.description.abstract |
<jats:p>Inflammation is central to several diseases. TLR4 mediates inflammation by recognising and binding to bacterial lipopolysaccharides and interacting with other proteins in the TLR4 signalling pathway. Although there is extensive research on TLR4-mediated inflammation, there are gaps in understanding its mechanisms. Recently, TLR4 co-localised with LPCAT2, a lysophospholipid acetyltransferase. LPCAT2 is already known to influence lipopolysaccharide-induced inflammation; however, the mechanism of LPCAT2 influencing lipopolysaccharide-mediated inflammation is not understood. This study combined computational analysis with biochemical analysis to investigate the influence of LPCAT2 on lysine acetylation in LPS-treated RAW264.7 cells. The results suggest for the first time that LPCAT2 influences lysine acetylation in LPS-treated RAW264.7 cells. Moreover, we detected acetylated lysine residues on TLR4. This study lays a foundation for further research on the role of lysine acetylation on TLR4 signalling. Moreover, further research is required to characterise LPCAT2 as a protein acetyltransferase.</jats:p> | |
dc.format.extent | BSR20220251- | |
dc.format.medium | ||
dc.language | en | |
dc.language.iso | eng | |
dc.publisher | Portland Press Ltd. | |
dc.subject | acetylation/deacetylation | |
dc.subject | acetyltransferases | |
dc.subject | bioinformatics | |
dc.subject | immunomodulation | |
dc.subject | inflammation | |
dc.subject | toll-like receptors | |
dc.subject | 1-Acylglycerophosphocholine O-Acyltransferase | |
dc.subject | Acetylation | |
dc.subject | Acetyltransferases | |
dc.subject | Animals | |
dc.subject | Inflammation | |
dc.subject | Lipopolysaccharides | |
dc.subject | Lysine | |
dc.subject | Mice | |
dc.subject | RAW 264.7 Cells | |
dc.subject | Toll-Like Receptor 4 | |
dc.title | Possible Regulation of Toll-Like Receptor 4 By Lysine Acetylation Through LPCAT2 Activity in RAW264.7 Cells. | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Research Support, Non-U.S. Gov't | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000830073400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 7 | |
plymouth.volume | 42 | |
plymouth.publication-status | Published | |
plymouth.journal | Bioscience Reports | |
dc.identifier.doi | 10.1042/bsr20220251 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/School of Biomedical Sciences | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | England | |
dcterms.dateAccepted | 2022-06-22 | |
dc.rights.embargodate | 2022-7-23 | |
dc.identifier.eissn | 1573-4935 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1042/bsr20220251 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2022-06-23 | |
rioxxterms.type | Journal Article/Review |