The Development and Internal Evaluation of a Predictive Model to Identify for Whom Mindfulness-Based Cognitive Therapy Offers Superior Relapse Prevention for Recurrent Depression Versus Maintenance Antidepressant Medication
dc.contributor.author | Cohen, ZD | |
dc.contributor.author | DeRubeis, RJ | |
dc.contributor.author | Hayes, R | |
dc.contributor.author | Watkins, ER | |
dc.contributor.author | Lewis, G | |
dc.contributor.author | Byng, Richard | |
dc.contributor.author | Byford, S | |
dc.contributor.author | Crane, C | |
dc.contributor.author | Kuyken, W | |
dc.contributor.author | Dalgleish, T | |
dc.contributor.author | Schweizer, S | |
dc.date.accessioned | 2022-06-28T12:31:21Z | |
dc.date.available | 2022-06-28T12:31:21Z | |
dc.date.issued | 2022-04-29 | |
dc.identifier.issn | 2167-7026 | |
dc.identifier.issn | 2167-7034 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/19351 | |
dc.description.abstract |
<jats:p> Depression is highly recurrent, even following successful pharmacological and/or psychological intervention. We aimed to develop clinical prediction models to inform adults with recurrent depression choosing between antidepressant medication (ADM) maintenance or switching to mindfulness-based cognitive therapy (MBCT). Using previously published data ( N = 424), we constructed prognostic models using elastic-net regression that combined demographic, clinical, and psychological factors to predict relapse at 24 months under ADM or MBCT. Only the ADM model (discrimination performance: area under the curve [AUC] = .68) predicted relapse better than baseline depression severity (AUC = .54; one-tailed DeLong’s test: z = 2.8, p = .003). Individuals with the poorest ADM prognoses who switched to MBCT had better outcomes compared with individuals who maintained ADM (48% vs. 70% relapse, respectively; superior survival times, z = −2.7, p = .008). For individuals with moderate to good ADM prognoses, both treatments resulted in similar likelihood of relapse. If replicated, the results suggest that predictive modeling can inform clinical decision-making around relapse prevention in recurrent depression. </jats:p> | |
dc.format.extent | 59-76 | |
dc.format.medium | Print-Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | SAGE Publications | |
dc.subject | antidepressant medication | |
dc.subject | depression | |
dc.subject | mindfulness-based cognitive therapy | |
dc.subject | precision medicine | |
dc.subject | relapse prevention | |
dc.title | The Development and Internal Evaluation of a Predictive Model to Identify for Whom Mindfulness-Based Cognitive Therapy Offers Superior Relapse Prevention for Recurrent Depression Versus Maintenance Antidepressant Medication | |
dc.type | journal-article | |
dc.type | Journal Article | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000789439100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 1 | |
plymouth.volume | 11 | |
plymouth.publication-status | Published | |
plymouth.journal | Clinical Psychological Science | |
dc.identifier.doi | 10.1177/21677026221076832 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/FoH - Community and Primary Care | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Health and Community | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CCT&PS | |
plymouth.organisational-group | /Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR) | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2022-01-11 | |
dc.rights.embargodate | 2022-6-29 | |
dc.identifier.eissn | 2167-7034 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1177/21677026221076832 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.type | Journal Article/Review |