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dc.contributor.authorRosenke, Ken
dc.contributor.authorFeldmann, Fen
dc.contributor.authorOkumura, Aen
dc.contributor.authorHansen, Fen
dc.contributor.authorTang-Huau, Ten
dc.contributor.authorMeade-White, Ken
dc.contributor.authorKaza, Ben
dc.contributor.authorSmith, BJen
dc.contributor.authorHanley, PWen
dc.contributor.authorLovaglio, Jen
dc.contributor.authorJarvis, MAen
dc.contributor.authorShaia, Cen
dc.contributor.authorFeldmann, Hen
dc.date.accessioned2022-05-24T08:44:35Z
dc.date.available2022-05-24T08:44:35Z
dc.date.issued2021-06-13en
dc.identifier.urihttp://hdl.handle.net/10026.1/19259
dc.description.abstract

The continuing emergence of SARS-CoV-2 variants calls for regular assessment to identify differences in viral replication, shedding and associated disease. In this study, African green monkeys were infected intranasally with either a contemporary D614G or the UK B.1.1.7 variant. Both variants caused mild respiratory disease with no significant differences in clinical presentation. Significantly higher levels of viral RNA and infectious virus were found in upper and lower respiratory tract samples and tissues from B.1.1.7 infected animals. Interestingly, D614G infected animals showed significantly higher levels of viral RNA and infectious virus in rectal swabs and gastrointestinal tract tissues. Our results indicate that B.1.1.7 infection in African green monkeys is associated with increased respiratory replication and shedding but no disease enhancement similar to human B.1.1.7 cases. ONE-SENTENCE SUMMARY: UK B.1.1.7 infection of African green monkeys exhibits increased respiratory replication and shedding but no disease enhancement.

en
dc.languageengen
dc.language.isoengen
dc.titleUK B.1.1.7 variant exhibits increased respiratory replication and shedding in nonhuman primates.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/34159332en
plymouth.publication-statusPublished onlineen
plymouth.journalbioRxiven
dc.identifier.doi10.1101/2021.06.11.448134en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Biomedical Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeUnited Statesen
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1101/2021.06.11.448134en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.typeJournal Article/Reviewen


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