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dc.contributor.authorHarpham, C
dc.contributor.authorHarpham, QK
dc.contributor.authorBarker, AR
dc.date.accessioned2022-05-14T12:38:14Z
dc.date.issued2022-03-10
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.urihttp://hdl.handle.net/10026.1/19224
dc.descriptionFile replaced (incorrect version) on 17/05/2022 by KT (LDS).
dc.description.abstract

<jats:title>Abstract</jats:title><jats:sec><jats:title>Aim</jats:title><jats:p>To examine the effect of exercise training programs with aerobic components on C‐reactive protein, erythrocyte sedimentation rate and self‐assessed disease activity in people with ankylosing spondylitis compared to non‐aerobic rehabilitation.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A systematic review was undertaken of PubMED, Cochrane Library, Embase and Web of Science databases. Articles evaluating the effect of exercise training programs with aerobic components on C‐reactive protein, erythrocyte sedimentation rate or Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in adults (&gt;17 years) with ankylosing spondylitis were included. Control groups were defined as non‐aerobic rehabilitation, including usual care or physiotherapy.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Thirteen articles met inclusion criteria for qualitative and meta‐analysis, involving 366 participants undertaking exercise and 361 controls. Exercise programs included modalities such as running, aerobic walking and swimming, and were between 3 weeks and 3 months in duration. Exercise programs significantly reduced C‐reactive protein (weighted mean difference [WMD]: −1.09; 95% CI: −2.08 to −0.10; <jats:italic>P</jats:italic> = .03; n = 5) and BASDAI (WMD: −0.78; 95% CI: −0.98 to −0.58; <jats:italic>P</jats:italic> &lt; .001; n = 13) compared to non‐aerobic rehabilitation. BASDAI subgroup analysis revealed greater improvements compared to usual care than structured physiotherapy. Exercise programs did not reduce erythrocyte sedimentation rate (WMD: 0.16; 95% CI: −2.15 to 2.47; <jats:italic>P</jats:italic> = .89; n = 4).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Exercise training programs with aerobic components reduced C‐reactive protein and improved self‐assessed disease activity in people with ankylosing spondylitis. Further research is required to investigate the effects of differing aerobic exercise modes, intensities and durations.</jats:p></jats:sec>

dc.format.extent635-649
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoeng
dc.publisherWiley
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectarthritis
dc.subjectfatigue
dc.subjectinflammation
dc.subjectpain
dc.subjectphysical activity
dc.titleThe effect of exercise training programs with aerobic components on C‐reactive protein, erythrocyte sedimentation rate and self‐assessed disease activity in people with ankylosing spondylitis: A systematic review and meta‐analysis
dc.typejournal-article
dc.typeJournal Article
dc.typeMeta-Analysis
dc.typeSystematic Review
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000767059700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue6
plymouth.volume25
plymouth.publication-statusPublished
plymouth.journalInternational Journal of Rheumatic Diseases
dc.identifier.doi10.1111/1756-185x.14315
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeEngland
dcterms.dateAccepted2022-03-10
dc.rights.embargodate2022-5-18
dc.identifier.eissn1756-185X
rioxxterms.versionofrecord10.1111/1756-185x.14315
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.licenseref.startdate2022-03-10
rioxxterms.typeJournal Article/Review


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