Lifting the lid on perioperative goal-directed therapy
dc.contributor.author | Martin, Daniel | |
dc.date.accessioned | 2022-04-28T12:31:16Z | |
dc.date.issued | 2021-10 | |
dc.identifier.issn | 0007-0912 | |
dc.identifier.issn | 1471-6771 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/19102 | |
dc.description.abstract |
The complex cellular interactions that underlie pathologies related to reduced oxygen delivery after surgery are poorly defined and difficult to measure. Heywood and colleagues explored the patterns of protein expression in skin biopsies taken from a subgroup of patients enrolled in a randomised trial designed to evaluate perioperative goal-directed therapy. One of their key findings was that a failure of participants to maintain preoperative systemic oxygen delivery was associated with an upregulation of intracellular proteins involved in counteracting oxidative stress. Their study highlights the importance of oxidative stress in the perioperative setting and suggests that maintenance of baseline oxygen delivery might be an important regulator of redox balance. | |
dc.format.extent | 508-510 | |
dc.format.medium | Print-Electronic | |
dc.language | en | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.subject | goal-directed therapy | |
dc.subject | oxidative stress | |
dc.subject | oxygen delivery | |
dc.subject | perioperative outcome | |
dc.subject | proteomics | |
dc.title | Lifting the lid on perioperative goal-directed therapy | |
dc.type | journal-article | |
dc.type | Editorial | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000714068900017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 4 | |
plymouth.volume | 127 | |
plymouth.publication-status | Published | |
plymouth.journal | British Journal of Anaesthesia | |
dc.identifier.doi | 10.1016/j.bja.2021.07.009 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | England | |
dcterms.dateAccepted | 2021-07-13 | |
dc.rights.embargodate | 2022-9-20 | |
dc.identifier.eissn | 1471-6771 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1016/j.bja.2021.07.009 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2021-10 | |
rioxxterms.type | Journal Article/Review |