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dc.contributor.authorD. Foey, A
dc.date.accessioned2022-03-08T14:12:23Z
dc.date.available2022-03-08T14:12:23Z
dc.date.issued2018-07-27
dc.identifier.issn2471-9552
dc.identifier.issn2471-9552
dc.identifier.urihttp://hdl.handle.net/10026.1/18921
dc.description.abstract

Editorial. Probiotics are live microbes conferring health benefit to the host, by reinforcing mucosal barrier integrity and functionality. Recently, attention has focussed on their immunomodulatory role: a microbial on-oوٴ switch mediating homeostatic/tolerogenic mucosal responses, whilst maintaining responsiveness to pathogenic infection [1]. As with pathogenic bacteria and their conserved pathogen associated molecular patterns (PAMPs), probiotics exhibit microbial associated molecular patterns (MAMPs), thus pattern recognition is fundamental to understanding how probiotics modulate immune fate decisions: activation or tolerisation. Probiotic MAMPs, include LTA, PGN, LPS, flaJellLn and CpG DNA; initiating Lnflammatory responses through recognition by pattern recognition receptors, TLR2, NOD1/NOD2, TLR4, TLR5, TLR9, respectively. PRR recognition of both pathogen and probiotic MAMPs highlights our limited understanding of pattern recognition definLnJ protective anti-pathogen responses or immunomodulatory responses to beneficLal microbes.

dc.format.extent1-2
dc.language.isoen
dc.publisherOMICS Publishing Group
dc.titleProbiotics: Microbial Experts in Immunomodulation of Mucosal Macrophage-Driven Responses
dc.typejournal-article
plymouth.issue1
plymouth.volume4
plymouth.publication-statusPublished online
plymouth.journalImmunotherapy: Open Access
dc.identifier.doi10.4172/2471-9552.1000e108
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Biomedical Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dcterms.dateAccepted2018-07-20
dc.rights.embargodate2022-3-9
dc.identifier.eissn2471-9552
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.4172/2471-9552.1000e108
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-07-27
rioxxterms.typeJournal Article/Review


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