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dc.contributor.authorLi, M
dc.contributor.authorMin, Q
dc.contributor.authorBanton, MC
dc.contributor.authorDun, X
dc.date.accessioned2022-02-08T14:18:11Z
dc.date.issued2021-12-08
dc.identifier.issn1662-5102
dc.identifier.issn1662-5102
dc.identifier.other676515
dc.identifier.urihttp://hdl.handle.net/10026.1/18706
dc.description.abstract

<jats:p>Advances in single-cell RNA sequencing technologies and bioinformatics methods allow for both the identification of cell types in a complex tissue and the large-scale gene expression profiling of various cell types in a mixture. In this report, we analyzed a single-cell RNA sequencing (scRNA-seq) dataset for the intact adult mouse sciatic nerve and examined cell-type specific transcription factor expression and activity during peripheral nerve homeostasis. In total, we identified 238 transcription factors expressed in nine different cell types of intact mouse sciatic nerve. Vascular smooth muscle cells have the lowest number of transcription factors expressed with 17 transcription factors identified. Myelinating Schwann cells (mSCs) have the highest number of transcription factors expressed, with 61 transcription factors identified. We created a cell-type specific expression map for the identified 238 transcription factors. Our results not only provide valuable information about the expression pattern of transcription factors in different cell types of adult peripheral nerves but also facilitate future studies to understand the function of key transcription factors in the peripheral nerve homeostasis and disease.</jats:p>

dc.format.extent676515-
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.language.isoen
dc.publisherFrontiers Media
dc.subjectperipheral nerves
dc.subjecttranscription factors
dc.subjectexpression
dc.subjectscRNA-seq
dc.subjectSCENIC
dc.titleSingle-Cell Regulatory Network Inference and Clustering Identifies Cell-Type Specific Expression Pattern of Transcription Factors in Mouse Sciatic Nerve
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/34955748
plymouth.volume15
plymouth.publisher-urlhttp://dx.doi.org/10.3389/fncel.2021.676515
plymouth.publication-statusPublished online
plymouth.journalFrontiers in Cellular Neuroscience
dc.identifier.doi10.3389/fncel.2021.676515
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Biomedical Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeSwitzerland
dcterms.dateAccepted2021-10-28
dc.rights.embargodate2022-2-11
dc.identifier.eissn1662-5102
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.3389/fncel.2021.676515
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-12-08
rioxxterms.typeJournal Article/Review


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