THE CRYSTAL AND MOLECULAR STRUCTURE OF NOVOBIOCIN

Abstract

Previous studies on the biological activity of the antibiotic novobiocin have indicated that this unique molecule is required intact for full antibacterial activity. Structure-activity investigations performed by other workers have not been able to ascribe its anti-bacterial activity to any one feature of the chemical structure. Single crystal X-ray techniques have therefore been used to determine the structure in the solid state in the hope that this will contribute to a better understanding of the mode of action of the drug.