UK B.1.1.7 (Alpha) variant exhibits increased respiratory replication and shedding in nonhuman primates
dc.contributor.author | Rosenke, K | |
dc.contributor.author | Feldmann, F | |
dc.contributor.author | Okumura, A | |
dc.contributor.author | Hansen, F | |
dc.contributor.author | Tang-Huau, T-L | |
dc.contributor.author | Meade-White, K | |
dc.contributor.author | Kaza, B | |
dc.contributor.author | Callison, J | |
dc.contributor.author | Lewis, MC | |
dc.contributor.author | Smith, BJ | |
dc.contributor.author | Hanley, PW | |
dc.contributor.author | Lovaglio, J | |
dc.contributor.author | Jarvis, Michael A | |
dc.contributor.author | Shaia, C | |
dc.contributor.author | Feldmann, H | |
dc.date.accessioned | 2021-12-02T10:44:49Z | |
dc.date.available | 2021-12-02T10:44:49Z | |
dc.date.issued | 2021-11-21 | |
dc.identifier.issn | 2222-1751 | |
dc.identifier.issn | 2222-1751 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/18431 | |
dc.description.abstract |
The continuing emergence of SARS-CoV-2 variants calls for regular assessment to identify differences in viral replication, shedding and associated disease. In this study, we compared African green monkeys infected intranasally with either the UK B.1.1.7 (Alpha) variant or its contemporary D614G progenitor. Both variants caused mild respiratory disease with no significant differences in clinical presentation. Significantly higher levels of viral RNA and infectious virus were found in upper and lower respiratory tract samples and tissues from B.1.1.7 infected animals. Interestingly, D614G infected animals showed significantly higher levels of viral RNA and infectious virus in rectal swabs and gastrointestinal tissues. Our results indicate that B.1.1.7 infection in African green monkeys is associated with increased respiratory replication and shedding but no disease enhancement similar to human B.1.1.7 cases. | |
dc.format.extent | 2173-2182 | |
dc.format.medium | ||
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Taylor & Francis Open Access | |
dc.subject | SARS-CoV-2 | |
dc.subject | variants of concern (VOC) | |
dc.subject | African green monkey | |
dc.subject | transmission | |
dc.subject | virulence | |
dc.title | UK B.1.1.7 (Alpha) variant exhibits increased respiratory replication and shedding in nonhuman primates | |
dc.type | journal-article | |
dc.type | Journal Article | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000720764100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 1 | |
plymouth.volume | 10 | |
plymouth.publication-status | Published | |
plymouth.journal | Emerging Microbes and Infections | |
dc.identifier.doi | 10.1080/22221751.2021.1997074 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/School of Biomedical Sciences | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2021-10-18 | |
dc.rights.embargodate | 2021-12-3 | |
dc.identifier.eissn | 2222-1751 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1080/22221751.2021.1997074 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2021-11-21 | |
rioxxterms.type | Journal Article/Review |