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dc.contributor.authorPohl, K
dc.contributor.authorMoodley, P
dc.contributor.authorDhanda, Ashwin
dc.date.accessioned2021-11-11T13:51:17Z
dc.date.issued2021-09-11
dc.identifier.issn2072-6643
dc.identifier.issn2072-6643
dc.identifier.otherARTN 3170
dc.identifier.urihttp://hdl.handle.net/10026.1/18325
dc.description.abstract

<jats:p>Alcohol is inextricably linked with the digestive system. It is absorbed through the gut and metabolised by hepatocytes within the liver. Excessive alcohol use results in alterations to the gut microbiome and gut epithelial integrity. It contributes to important micronutrient deficiencies including short-chain fatty acids and trace elements that can influence immune function and lead to liver damage. In some people, long-term alcohol misuse results in liver disease progressing from fatty liver to cirrhosis and hepatocellular carcinoma, and results in over half of all deaths from chronic liver disease, over half a million globally per year. In this review, we will describe the effect of alcohol on the gut, the gut microbiome and liver function and structure, with a specific focus on micronutrients and areas for future research.</jats:p>

dc.format.extent3170-3170
dc.format.mediumElectronic
dc.languageen
dc.language.isoen
dc.publisherMDPI
dc.subjectalcohol
dc.subjectgut
dc.subjectliver
dc.subjectcirrhosis
dc.subjecthepatocellular carcinoma
dc.subjectmicrobiome
dc.titleAlcohol’s Impact on the Gut and Liver
dc.typejournal-article
dc.typeJournal Article
dc.typeReview
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000699920600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue9
plymouth.volume13
plymouth.publication-statusPublished online
plymouth.journalNutrients
dc.identifier.doi10.3390/nu13093170
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR)
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
plymouth.organisational-group/Plymouth/Users by role/Researchers in ResearchFish submission
dc.publisher.placeSwitzerland
dcterms.dateAccepted2021-09-07
dc.rights.embargodate2021-11-12
dc.identifier.eissn2072-6643
dc.rights.embargoperiodNot known
rioxxterms.funderNational Institute for Health Research
rioxxterms.identifier.projectNIHR Academic Clinical Fellowship
rioxxterms.versionofrecord10.3390/nu13093170
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-09-11
rioxxterms.typeJournal Article/Review
plymouth.funderNIHR Academic Clinical Fellowship::National Institute for Health Research


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