Alcohol’s Impact on the Gut and Liver
dc.contributor.author | Pohl, K | |
dc.contributor.author | Moodley, P | |
dc.contributor.author | Dhanda, Ashwin | |
dc.date.accessioned | 2021-11-11T13:51:17Z | |
dc.date.issued | 2021-09-11 | |
dc.identifier.issn | 2072-6643 | |
dc.identifier.issn | 2072-6643 | |
dc.identifier.other | ARTN 3170 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/18325 | |
dc.description.abstract |
<jats:p>Alcohol is inextricably linked with the digestive system. It is absorbed through the gut and metabolised by hepatocytes within the liver. Excessive alcohol use results in alterations to the gut microbiome and gut epithelial integrity. It contributes to important micronutrient deficiencies including short-chain fatty acids and trace elements that can influence immune function and lead to liver damage. In some people, long-term alcohol misuse results in liver disease progressing from fatty liver to cirrhosis and hepatocellular carcinoma, and results in over half of all deaths from chronic liver disease, over half a million globally per year. In this review, we will describe the effect of alcohol on the gut, the gut microbiome and liver function and structure, with a specific focus on micronutrients and areas for future research.</jats:p> | |
dc.format.extent | 3170-3170 | |
dc.format.medium | Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | MDPI | |
dc.subject | alcohol | |
dc.subject | gut | |
dc.subject | liver | |
dc.subject | cirrhosis | |
dc.subject | hepatocellular carcinoma | |
dc.subject | microbiome | |
dc.title | Alcohol’s Impact on the Gut and Liver | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Review | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000699920600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 9 | |
plymouth.volume | 13 | |
plymouth.publication-status | Published online | |
plymouth.journal | Nutrients | |
dc.identifier.doi | 10.3390/nu13093170 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR) | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | Switzerland | |
dcterms.dateAccepted | 2021-09-07 | |
dc.rights.embargodate | 2021-11-12 | |
dc.identifier.eissn | 2072-6643 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.funder | National Institute for Health Research | |
rioxxterms.identifier.project | NIHR Academic Clinical Fellowship | |
rioxxterms.versionofrecord | 10.3390/nu13093170 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2021-09-11 | |
rioxxterms.type | Journal Article/Review | |
plymouth.funder | NIHR Academic Clinical Fellowship::National Institute for Health Research |