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dc.contributor.authorHyland, MEen
dc.contributor.authorLanario, JWen
dc.contributor.authorMenzies-Gow, Aen
dc.contributor.authorMansur, AHen
dc.contributor.authorDodd, JWen
dc.contributor.authorFowler, SJen
dc.contributor.authorHayes, Gen
dc.contributor.authorJones, RCen
dc.contributor.authorMasoli, Men
dc.date.accessioned2021-11-10T16:56:09Z
dc.date.available2021-11-10T16:56:09Z
dc.date.issued2021-01-01en
dc.identifier.issn1479-9723en
dc.identifier.other147997312110435en
dc.identifier.urihttp://hdl.handle.net/10026.1/18314
dc.description.abstract

<jats:p> Background </jats:p><jats:p> The sensitivity of patient-reported outcomes (PROs) to detect the effects of treatment change depends on the match between the change in items of the PRO and the change that takes place in a sample of people. The aim of this study is to compare the sensitivity of different PROs in detecting changes following the initiation of biologic treatment in asthma. Methods: Patients starting a biologic treatment as part of clinical care completed the Asthma Control Questionnaire (ACQ-6), the Severe Asthma Questionnaire (SAQ and SAQ-global scores) and the EQ5D (EQ-5D-5L and EQ5D-VAS) at baseline. They completed the ACQ-6, SAQ, SAQ-global and a retrospective global rating of change (GRoC) scale at weeks 4, 8 and 16 and completed the EQ-5D-5L and EQ5D-VAS at week 16. The SAQ-global and EQ5D-VAS differ but both are single item 100-point questions. Sensitivity was measured by Cohen’s D effect size at each of the three time points. Results: 110 patients were recruited. Depending on the time of assessment, effect size varied between 0.45 and 0.64 for the SAQ, between 0.50 and 0.77 for the SAQ-global; between 0.45 and 0.69 for ACQ-6; between 0.91 and 1.22 for GRoC; 0.32 for EQ-5D-5L and 0.49 for EQ5D-VAS. Conclusion: The sensitivity to change of a questionnaire varies with the time of measurement. The three asthma-specific prospective measures (SAQ, SAQ-global and ACQ-6) have similar sensitivity to change. The single-item EQ5D-VAS was less sensitive than the asthma specific measures and less sensitive than the single-item SAQ-global. The EQ-5D-5L was least sensitive. </jats:p>

en
dc.languageenen
dc.language.isoenen
dc.publisherSAGE Publicationsen
dc.titleComparison of the sensitivity of patient-reported outcomes for detecting the benefit of biologics in severe asthmaen
dc.typeJournal Article
plymouth.volume18en
plymouth.journalChronic Respiratory Diseaseen
dc.identifier.doi10.1177/14799731211043530en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy MANUAL
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Centre for Brain, Cognition and Behaviour (CBCB)
plymouth.organisational-group/Plymouth/Research Groups/Centre for Brain, Cognition and Behaviour (CBCB)/Behaviour
plymouth.organisational-group/Plymouth/Research Groups/FoH - Community and Primary Care
plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CCT&PS
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dcterms.dateAccepted2021-08-13en
dc.rights.embargodate2021-11-12en
dc.identifier.eissn1479-9731en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1177/14799731211043530en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2021-01-01en
rioxxterms.typeJournal Article/Reviewen


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