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dc.contributor.authorEthunandan, Men
dc.contributor.authorWitton, Ren
dc.contributor.authorHoffman, Gen
dc.contributor.authorSpedding, Aen
dc.contributor.authorBrennan, PAen
dc.date.accessioned2021-11-09T21:00:03Z
dc.date.available2021-11-09T21:00:03Z
dc.date.issued2006-07en
dc.identifier.issn0901-5027en
dc.identifier.urihttp://hdl.handle.net/10026.1/18300
dc.description.abstract

Pleomorphic adenoma is the most common salivary gland neoplasm and infrequently undergoes malignant transformation. Carcinoma ex pleomorphic adenoma is typically an infiltrative neoplasm with features of cellular pleomorphism, high mitotic activity, peri-neural and vascular invasion. More recently, sub-groups of pleomorphic adenoma have been described exhibiting vascular invasion and features of malignancy without evidence of extra-capsular extension. There is little information in the literature regarding how these different histological variants influence clinical presentation and outcome following primary treatment. Following a review of 100 consecutive pleomorphic adenomas removed from the major salivary glands, 4 cases with atypical histological features were found. Three tumours exhibited features of dysplasia/carcinoma without evidence of extra-capsular invasion and a further case demonstrated benign vascular invasion. There were no clinical features suggestive of the atypical nature of these neoplasms, though fine needle aspiration cytology (FNAC) was suspicious of a malignancy in 2 cases and CT scan in 1 case. Patients underwent a superficial parotidectomy or submandibular gland excision based on the location of the lesion. All lesions were completely excised and there were no recurrences in this series.

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dc.format.extent608 - 612en
dc.languageengen
dc.language.isoengen
dc.subjectAdenoma, Pleomorphicen
dc.subjectAgeden
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectRetrospective Studiesen
dc.subjectSalivary Gland Neoplasmsen
dc.titleAtypical features in pleomorphic adenoma--a clinicopathologic study and implications for management.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/16540285en
plymouth.issue7en
plymouth.volume35en
plymouth.publication-statusPublisheden
plymouth.journalInt J Oral Maxillofac Surgen
dc.identifier.doi10.1016/j.ijom.2006.02.009en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Dental School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeDenmarken
dcterms.dateAccepted2006-02-06en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1016/j.ijom.2006.02.009en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2006-07en
rioxxterms.typeJournal Article/Reviewen


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