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dc.contributor.authorKonda, NN
dc.contributor.authorKarri, RS
dc.contributor.authorWinnard, A
dc.contributor.authorNasser, Mona
dc.contributor.authorEvetts, S
dc.contributor.authorBoudreau, E
dc.contributor.authorCaplan, N
dc.contributor.authorGradwell, D
dc.contributor.authorVelho, RM
dc.date.accessioned2021-09-17T12:10:40Z
dc.date.issued2019-05-08
dc.identifier.issn2373-8065
dc.identifier.issn2373-8065
dc.identifier.other12
dc.identifier.urihttp://hdl.handle.net/10026.1/17817
dc.description.abstract

<jats:title>Abstract</jats:title><jats:p>Musculoskeletal loss in actual or simulated microgravity occurs at a high rate. Bed rest studies are a reliable ground-based spaceflight analogue that allow for direct comparison of intervention and control participants. The aim of this review was to investigate the impact of exercise compared to no intervention on bone mineral density (BMD) and muscle cross-sectional area (muscle CSA) in bed rest studies relative to other terrestrial models. Eligible bed rest studies with healthy participants had an intervention arm with an exercise countermeasure and a control arm. A search strategy was implemented for MEDLINE. After screening, eight studies were identified for inclusion. Interventions included resistive exercise (RE), resistive vibration exercise (RVE), flywheel resistive exercise, treadmill exercise with lower body negative pressure (LBNP) and a zero-gravity locomotion simulator (ZLS). Lower limb skeletal sites had the most significant BMD losses, particularly at the hip which reduced in density by 4.59% (<jats:italic>p</jats:italic> &lt; 0.05) and the tibial epiphysis by 6% (<jats:italic>p</jats:italic> &lt; 0.05). Exercise attenuated bone loss at the hip and distal tibia compared to controls (<jats:italic>p</jats:italic> &lt; 0.05). Muscle CSA changes indicated that the calf and quadriceps were most affected by bed rest. Exercise interventions significantly attenuated loss of muscle mass. ZLS, LBNP treadmill and RE significantly attenuated bone and muscle loss at the hip compared to baseline and controls. Despite exercise intervention, high rates of bone loss were still observed. Future studies should consider adding bisphosphonates and pharmacological/nutrition-based interventions for consideration of longer-duration missions. These findings correlate to terrestrial bed rest settings, for example, stroke or spinal-injury patients.</jats:p>

dc.format.extent12-
dc.format.mediumElectronic-eCollection
dc.languageen
dc.language.isoen
dc.publisherNature Research (part of Springer Nature)
dc.subjectAnatomy
dc.subjectOutcomes research
dc.titleA comparison of exercise interventions from bed rest studies for the prevention of musculoskeletal loss
dc.typejournal-article
dc.typeJournal Article
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000467310900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue1
plymouth.volume5
plymouth.publication-statusPublished online
plymouth.journalnpj Microgravity
dc.identifier.doi10.1038/s41526-019-0073-4
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Admin Group - REF
plymouth.organisational-group/Plymouth/Admin Group - REF/REF Admin Group - FoH
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Dental School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CCT&PS
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeUnited States
dcterms.dateAccepted2019-03-14
dc.rights.embargodate2021-9-18
dc.identifier.eissn2373-8065
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1038/s41526-019-0073-4
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-05-08
rioxxterms.typeJournal Article/Review


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