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dc.contributor.authorLiew, Nen
dc.contributor.authorMazon Moya, MJen
dc.contributor.authorWierzbicki, CJen
dc.contributor.authorHollinshead, Men
dc.contributor.authorDillon, MJen
dc.contributor.authorThornton, CRen
dc.contributor.authorEllison, Aen
dc.contributor.authorCable, Jen
dc.contributor.authorFisher, MCen
dc.contributor.authorMostowy, Sen
dc.date.accessioned2021-09-16T14:33:27Z
dc.date.available2021-09-16T14:33:27Z
dc.date.issued2017-04-20en
dc.identifier.urihttp://hdl.handle.net/10026.1/17804
dc.description.abstract

Aquatic chytrid fungi threaten amphibian biodiversity worldwide owing to their ability to rapidly expand their geographical distributions and to infect a wide range of hosts. Combating this risk requires an understanding of chytrid host range to identify potential reservoirs of infection and to safeguard uninfected regions through enhanced biosecurity. Here we extend our knowledge on the host range of the chytrid Batrachochytrium dendrobatidis by demonstrating infection of a non-amphibian vertebrate host, the zebrafish. We observe dose-dependent mortality and show that chytrid can infect and proliferate on zebrafish tissue. We also show that infection phenotypes (fin erosion, cell apoptosis and muscle degeneration) are direct symptoms of infection. Successful infection is dependent on disrupting the zebrafish microbiome, highlighting that, as is widely found in amphibians, commensal bacteria confer protection against this pathogen. Collectively, our findings greatly expand the limited tool kit available to study pathogenesis and host response to chytrid infection.

en
dc.format.extent15048 - ?en
dc.languageengen
dc.language.isoengen
dc.subjectAmphibiansen
dc.subjectAnimal Finsen
dc.subjectAnimalsen
dc.subjectChytridiomycotaen
dc.subjectFish Diseasesen
dc.subjectHost-Pathogen Interactionsen
dc.subjectMicrobial Interactionsen
dc.subjectMicrobiotaen
dc.subjectZebrafishen
dc.titleChytrid fungus infection in zebrafish demonstrates that the pathogen can parasitize non-amphibian vertebrate hosts.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/28425465en
plymouth.volume8en
plymouth.publication-statusPublished onlineen
plymouth.journalNat Communen
dc.identifier.doi10.1038/ncomms15048en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeEnglanden
dcterms.dateAccepted2017-02-23en
dc.identifier.eissn2041-1723en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1038/ncomms15048en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-04-20en
rioxxterms.typeJournal Article/Reviewen


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