Show simple item record

dc.contributor.supervisorRoser, Matthew
dc.contributor.authorKharko, Anna
dc.contributor.otherFaculty of Health: Medicine, Dentistry and Human Sciencesen_US

Understanding pain is integral to understanding fibromyalgia, a chronic musculoskeletal pain condition of undetermined aetiology, and for which no single successful medical therapy exists. Most of what is known about fibromyalgia pain comes from psychophysical research of central sensitisation, a phenomenon of abnormally amplified pain following disruptions in the central nervous system. Anxiety has been long theorised to mediate this centralised pain, but its contribution is yet to be characterised.

This thesis presents a multimodal investigation of pain perception under different manifestations of anxiety in both fibromyalgia-diagnosed and pain-free cohorts.

Chapter 3 presented the findings from the first study in the series of PhD research, in which a novel method for gathering pain ratings was tested. Continuous pain report allowed for the extraction of novel measures, which characterised the unique properties of pain processing in fibromyalgia.

Chapter 4 described a study with pain-free participants, in which, for the first time, continuous pain ratings were combined with concurrent modulation and report of experimentally maintained acute anxiety. Results indicated that anxiety evoked through the 7.5% CO2 Model is associated with an overall decrease of reported pain but not with individual measures, extracted from the pain response.

Chapter 5 further adopted the successful pain and anxiety experimental paradigm and tested its feasibility with fibromyalgia-diagnosed participants. The limited success of the study discouraged further use of the CO2 Model with that patient population but highlighted the significance of anxiety for that condition.

The final chapter, Chapter 6, explored the role of anxiety under a different taxonomy, as sustained psychological distress evoked by the COVID-19 pandemic. In an observational study, it was revealed that fluctuations in sustained anxiety are mirrored by changes in reported pain intensity.

Together, the findings support that the study of anxiety advances the understanding of fibromyalgia pain processing, and argue for the continued research of both their momentary and long-term interaction for the comprehensive understanding of their relationship.

dc.publisherUniversity of Plymouth
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.subjectacute painen_US
dc.subjectchronic painen_US
dc.subjectacute anxietyen_US
dc.subject7.5% CO2en_US
dc.subjectsustained anxietyen_US
dc.titleThe Psychology of Anxiety & Pain in Fibromyalgiaen_US
dc.rights.embargoperiod12 monthsen_US

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

All items in PEARL are protected by copyright law.
Author manuscripts deposited to comply with open access mandates are made available in accordance with publisher policies. Please cite only the published version using the details provided on the item record or document. In the absence of an open licence (e.g. Creative Commons), permissions for further reuse of content should be sought from the publisher or author.
Theme by 
@mire NV