Plasma Free Fatty Acids Metabolic Profile with LC-MS and Appetite-Related Hormones in South Asian and White European Men in Relation to Adiposity, Physical Activity and Cardiorespiratory Fitness: A Cross-Sectional Study
dc.contributor.author | Benedetti, S | |
dc.contributor.author | Al-Tannak, NF | |
dc.contributor.author | Alzharani, M | |
dc.contributor.author | Moir, HJ | |
dc.contributor.author | Stensel, DJ | |
dc.contributor.author | Thackray, AE | |
dc.contributor.author | Naughton, DP | |
dc.contributor.author | Dorak, MT | |
dc.contributor.author | Spendiff, O | |
dc.contributor.author | Hill, Natasha | |
dc.contributor.author | Watson, DG | |
dc.contributor.author | Allgrove, J | |
dc.date.accessioned | 2021-08-13T10:21:13Z | |
dc.date.issued | 2019-04 | |
dc.identifier.issn | 2218-1989 | |
dc.identifier.issn | 2218-1989 | |
dc.identifier.other | ARTN 71 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/17578 | |
dc.description.abstract |
<jats:p>South Asians have a greater cardiovascular disease (CVD) and type 2 diabetes (T2D) risk than white Europeans, but the mechanisms are poorly understood. This study examined ethnic differences in free fatty acids (FFAs) metabolic profile (assessed using liquid chromatography-mass spectrometry), appetite-related hormones and traditional CVD and T2D risk markers in blood samples collected from 16 South Asian and 16 white European men and explored associations with body composition, objectively-measured physical activity and cardiorespiratory fitness. South Asians exhibited higher concentrations of five FFAs (laurate, myristate, palmitate, linolenic, linoleate; p ≤ 0.040), lower acylated ghrelin (ES = 1.00, p = 0.008) and higher leptin (ES = 1.11, p = 0.004) than white Europeans; total peptide YY was similar between groups (p = 0.381). South Asians exhibited elevated fasting insulin, C-reactive protein, interleukin-6, triacylglycerol and ratio of total cholesterol to high-density lipoprotein cholesterol (HDL-C) and lower fasting HDL-C (all ES ≥ 0.74, p ≤ 0.053). Controlling for body fat percentage (assessed using air displacement plethysmography) attenuated these differences. Despite similar habitual moderate-to-vigorous physical activity (ES = 0.18, p = 0.675), V ˙ O2max was lower in South Asians (ES = 1.36, p = 0.001). Circulating FFAs in South Asians were positively correlated with body fat percentage (r2 = 0.92), body mass (r2 = 0.86) and AUC glucose (r2 = 0.89) whereas in white Europeans FFAs were negatively correlated with total step counts (r2 = 0.96). In conclusion, South Asians exhibited a different FFA profile, lower ghrelin, higher leptin, impaired CVD and T2D risk markers and lower cardiorespiratory fitness than white Europeans.</jats:p> | |
dc.format.extent | 71-71 | |
dc.format.medium | Electronic | |
dc.language | en | |
dc.language.iso | eng | |
dc.publisher | MDPI AG | |
dc.subject | metabolomics | |
dc.subject | free fatty acids | |
dc.subject | cardiovascular disease | |
dc.subject | Type 2 diabetes | |
dc.subject | South Asian | |
dc.subject | physical activity | |
dc.subject | cardiorespiratory fitness | |
dc.subject | inflammation | |
dc.subject | appetite hormones | |
dc.subject | metabolic markers | |
dc.title | Plasma Free Fatty Acids Metabolic Profile with LC-MS and Appetite-Related Hormones in South Asian and White European Men in Relation to Adiposity, Physical Activity and Cardiorespiratory Fitness: A Cross-Sectional Study | |
dc.type | journal-article | |
dc.type | Journal Article | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000467305100012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 4 | |
plymouth.volume | 9 | |
plymouth.publication-status | Published online | |
plymouth.journal | Metabolites | |
dc.identifier.doi | 10.3390/metabo9040071 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/School of Biomedical Sciences | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | Switzerland | |
dcterms.dateAccepted | 2019-04-11 | |
dc.rights.embargodate | 9999-12-31 | |
dc.identifier.eissn | 2218-1989 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.3390/metabo9040071 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2019-04-13 | |
rioxxterms.type | Journal Article/Review |