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dc.contributor.authorBenedetti, S
dc.contributor.authorAl-Tannak, NF
dc.contributor.authorAlzharani, M
dc.contributor.authorMoir, HJ
dc.contributor.authorStensel, DJ
dc.contributor.authorThackray, AE
dc.contributor.authorNaughton, DP
dc.contributor.authorDorak, MT
dc.contributor.authorSpendiff, O
dc.contributor.authorHill, N
dc.contributor.authorWatson, DG
dc.contributor.authorAllgrove, J
dc.date.accessioned2021-08-13T10:21:13Z
dc.date.issued2019
dc.identifier.issn2218-1989
dc.identifier.issn2218-1989
dc.identifier.otherARTN 71
dc.identifier.urihttp://hdl.handle.net/10026.1/17578
dc.description.abstract

<jats:p>South Asians have a greater cardiovascular disease (CVD) and type 2 diabetes (T2D) risk than white Europeans, but the mechanisms are poorly understood. This study examined ethnic differences in free fatty acids (FFAs) metabolic profile (assessed using liquid chromatography-mass spectrometry), appetite-related hormones and traditional CVD and T2D risk markers in blood samples collected from 16 South Asian and 16 white European men and explored associations with body composition, objectively-measured physical activity and cardiorespiratory fitness. South Asians exhibited higher concentrations of five FFAs (laurate, myristate, palmitate, linolenic, linoleate; p ≤ 0.040), lower acylated ghrelin (ES = 1.00, p = 0.008) and higher leptin (ES = 1.11, p = 0.004) than white Europeans; total peptide YY was similar between groups (p = 0.381). South Asians exhibited elevated fasting insulin, C-reactive protein, interleukin-6, triacylglycerol and ratio of total cholesterol to high-density lipoprotein cholesterol (HDL-C) and lower fasting HDL-C (all ES ≥ 0.74, p ≤ 0.053). Controlling for body fat percentage (assessed using air displacement plethysmography) attenuated these differences. Despite similar habitual moderate-to-vigorous physical activity (ES = 0.18, p = 0.675), V ˙ O2max was lower in South Asians (ES = 1.36, p = 0.001). Circulating FFAs in South Asians were positively correlated with body fat percentage (r2 = 0.92), body mass (r2 = 0.86) and AUC glucose (r2 = 0.89) whereas in white Europeans FFAs were negatively correlated with total step counts (r2 = 0.96). In conclusion, South Asians exhibited a different FFA profile, lower ghrelin, higher leptin, impaired CVD and T2D risk markers and lower cardiorespiratory fitness than white Europeans.</jats:p>

dc.format.extent71-71
dc.format.mediumElectronic
dc.languageen
dc.language.isoeng
dc.publisherMDPI AG
dc.subjectmetabolomics
dc.subjectfree fatty acids
dc.subjectcardiovascular disease
dc.subjectType 2 diabetes
dc.subjectSouth Asian
dc.subjectphysical activity
dc.subjectcardiorespiratory fitness
dc.subjectinflammation
dc.subjectappetite hormones
dc.subjectmetabolic markers
dc.titlePlasma Free Fatty Acids Metabolic Profile with LC-MS and Appetite-Related Hormones in South Asian and White European Men in Relation to Adiposity, Physical Activity and Cardiorespiratory Fitness: A Cross-Sectional Study
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/31013892
plymouth.issue4
plymouth.volume9
plymouth.publisher-urlhttp://dx.doi.org/10.3390/metabo9040071
plymouth.publication-statusPublished online
plymouth.journalMetabolites
dc.identifier.doi10.3390/metabo9040071
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Biomedical Sciences
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeSwitzerland
dcterms.dateAccepted2019-04-11
dc.rights.embargodate9999-12-31
dc.identifier.eissn2218-1989
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.3390/metabo9040071
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-04-13
rioxxterms.typeJournal Article/Review


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