Recurrent Chronic HEV in Severe Combined Immunodeficiency
Date
2021-02-22Author
Moodley, P
Whyte, AF
Dhanda, Ashwin
Subject
Adult Antibodies, Viral Antiviral Agents Chronic Disease Female Hepatitis E Hepatitis E virus Humans Immunoglobulin G Immunoglobulin M Janus Kinase 3 RNA, Viral Recurrence Ribavirin Severe Combined Immunodeficiency T-Lymphocytes
Metadata
Show full item recordAbstract
Severe combined immunodeficiency (SCID) is a group of genetic disorders characterized by significant impairment of T cell differentiation, with or without abnormal B and NK cell differentiation. Without hematopoietic stem cell transplant (HSCT), the condition usually leads to an early death, typically due to infections. The most frequent genetic cause of SCID affects the common gamma chain, necessary for cytokine signaling. A similar phenotype is observed with mutations in the Janus-associated kinase 3 (JAK3) gene, the immediate downstream signaling molecule
Description
File replaced (docx to pdf) on 27.4.23 by NK (LDS)
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Publisher
Springer (part of Springer Nature)
Place of Publication
Netherlands
Journal
Journal of Clinical Immunology
Volume
41
Issue
5
Pagination
1103-1105
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