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dc.contributor.authorLeese, HJen
dc.contributor.authorSathyapalan, Ten
dc.contributor.authorAllgar, Ven
dc.contributor.authorBrison, DRen
dc.contributor.authorSturmey, Ren
dc.date.accessioned2021-08-09T11:22:03Z
dc.date.available2021-08-09T11:22:03Z
dc.date.issued2019-11-27en
dc.identifier.urihttp://hdl.handle.net/10026.1/17472
dc.description.abstract

Numerical data in biology and medicine are commonly presented as mean or median with error or confidence limits, to the exclusion of individual values. Analysis of our own and others' data indicates that this practice risks excluding 'Goldilocks' effects in which a biological variable falls within a range between 'too much' and 'too little' with a region between where its function is 'just right'; a concept captured by the Swedish term 'Lagom'. This was confirmed by a narrative search of the literature using the PubMed database, which revealed numerous relationships of biological and clinical phenomena of the Goldilocks/Lagom form including quantitative and qualitative examples from the health and social sciences. Some possible mechanisms underlying these phenomena are considered. We conclude that retrospective analysis of existing data will most likely reveal a vast number of such distributions to the benefit of medical understanding and clinical care and that a transparent approach of presenting each value within a dataset individually should be adopted to ensure a more complete evaluation of research studies in future.

en
dc.format.extente027767 - ?en
dc.languageengen
dc.language.isoengen
dc.subjectdata analysis and interpretationen
dc.subjectdata distributionsen
dc.subjectstatistics & research methodsen
dc.subjectAnimalsen
dc.subjectBiostatisticsen
dc.subjectBlastocysten
dc.subjectData Interpretation, Statisticalen
dc.subjectEmbryo Implantationen
dc.subjectGlycated Hemoglobin Aen
dc.subjectHumansen
dc.subjectRetrospective Studiesen
dc.titleGoing to extremes: the Goldilocks/Lagom principle and data distribution.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/31780584en
plymouth.issue11en
plymouth.volume9en
plymouth.publication-statusPublished onlineen
plymouth.journalBMJ Openen
dc.identifier.doi10.1136/bmjopen-2018-027767en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR)
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeEnglanden
dc.identifier.eissn2044-6055en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1136/bmjopen-2018-027767en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.typeJournal Article/Reviewen


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