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dc.contributor.authorDay, JOen
dc.contributor.authorMullin, Sen
dc.date.accessioned2021-07-02T15:42:03Z
dc.date.available2021-07-02T15:42:03Z
dc.date.issued2021-06-30en
dc.identifier.urihttp://hdl.handle.net/10026.1/17300
dc.description.abstract

<jats:p>The genetic landscape of Parkinson’s disease (PD) is characterised by rare high penetrance pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a significant minority in PD cases and high frequency, low penetrance variants, which contribute a small increase of the risk of developing sporadic PD. This knowledge has the potential to have a major impact in the clinical care of people with PD. We summarise these genetic influences and discuss the implications for therapeutics and clinical trial design.</jats:p>

en
dc.format.extent1006 - 1006en
dc.languageenen
dc.language.isoenen
dc.publisherMDPI AGen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleThe Genetics of Parkinson’s Disease and Implications for Clinical Practiceen
dc.typeJournal Article
plymouth.issue7en
plymouth.volume12en
plymouth.journalGenesen
dc.identifier.doi10.3390/genes12071006en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
plymouth.organisational-group/Plymouth/Users by role/Professional Services staff
dcterms.dateAccepted2021-06-28en
dc.rights.embargodate2021-07-06en
dc.identifier.eissn2073-4425en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.3390/genes12071006en
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2021-06-30en
rioxxterms.typeJournal Article/Reviewen


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