The Genetics of Parkinson’s Disease and Implications for Clinical Practice
| dc.contributor.author | Day, Jacob | |
| dc.contributor.author | Mullin, Stephen | |
| dc.date.accessioned | 2021-07-02T15:42:03Z | |
| dc.date.available | 2021-07-02T15:42:03Z | |
| dc.date.issued | 2021-06-30 | |
| dc.identifier.issn | 2073-4425 | |
| dc.identifier.issn | 2073-4425 | |
| dc.identifier.other | ARTN 1006 | |
| dc.identifier.uri | http://hdl.handle.net/10026.1/17300 | |
| dc.description.abstract |
<jats:p>The genetic landscape of Parkinson’s disease (PD) is characterised by rare high penetrance pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a significant minority in PD cases and high frequency, low penetrance variants, which contribute a small increase of the risk of developing sporadic PD. This knowledge has the potential to have a major impact in the clinical care of people with PD. We summarise these genetic influences and discuss the implications for therapeutics and clinical trial design.</jats:p> | |
| dc.format.extent | 1006-1006 | |
| dc.format.medium | Electronic | |
| dc.language | en | |
| dc.language.iso | en | |
| dc.publisher | MDPI AG | |
| dc.rights | Attribution 4.0 International | |
| dc.rights | Attribution 4.0 International | |
| dc.rights | Attribution 4.0 International | |
| dc.rights | Attribution 4.0 International | |
| dc.rights | Attribution 4.0 International | |
| dc.rights | Attribution 4.0 International | |
| dc.rights | Attribution 4.0 International | |
| dc.rights | Attribution 4.0 International | |
| dc.rights | Attribution 4.0 International | |
| dc.rights | Attribution 4.0 International | |
| dc.rights | Attribution 4.0 International | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Parkinson's disease | |
| dc.subject | genetics | |
| dc.subject | precision medicine | |
| dc.subject | clinical trials | |
| dc.subject | monogenic | |
| dc.subject | polygenic | |
| dc.title | The Genetics of Parkinson’s Disease and Implications for Clinical Practice | |
| dc.type | journal-article | |
| dc.type | Journal Article | |
| dc.type | Research Support, Non-U.S. Gov't | |
| dc.type | Review | |
| plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000676278300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
| plymouth.issue | 7 | |
| plymouth.volume | 12 | |
| plymouth.publication-status | Published online | |
| plymouth.journal | Genes | |
| dc.identifier.doi | 10.3390/genes12071006 | |
| plymouth.organisational-group | /Plymouth | |
| plymouth.organisational-group | /Plymouth/Faculty of Health | |
| plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
| plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
| plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
| plymouth.organisational-group | /Plymouth/Research Groups | |
| plymouth.organisational-group | /Plymouth/Research Groups/FoH - Applied Parkinson's Research | |
| plymouth.organisational-group | /Plymouth/Research Groups/FoH - Community and Primary Care | |
| plymouth.organisational-group | /Plymouth/Users by role | |
| plymouth.organisational-group | /Plymouth/Users by role/Academics | |
| plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
| dc.publisher.place | Switzerland | |
| dcterms.dateAccepted | 2021-06-28 | |
| dc.rights.embargodate | 2021-7-6 | |
| dc.identifier.eissn | 2073-4425 | |
| dc.rights.embargoperiod | Not known | |
| rioxxterms.funder | National Institute for Health Research | |
| rioxxterms.identifier.project | NIHR Academic Clinical Fellowship | |
| rioxxterms.versionofrecord | 10.3390/genes12071006 | |
| rioxxterms.licenseref.uri | http://creativecommons.org/licenses/by/4.0/ | |
| rioxxterms.licenseref.startdate | 2021-06-30 | |
| rioxxterms.type | Journal Article/Review | |
| plymouth.funder | NIHR Academic Clinical Fellowship::National Institute for Health Research |
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