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dc.contributor.authorDay, JO
dc.contributor.authorMullin, S
dc.date.accessioned2021-07-02T15:42:03Z
dc.date.available2021-07-02T15:42:03Z
dc.date.issued2021-06-30
dc.identifier.issn2073-4425
dc.identifier.issn2073-4425
dc.identifier.otherARTN 1006
dc.identifier.urihttp://hdl.handle.net/10026.1/17300
dc.description.abstract

<jats:p>The genetic landscape of Parkinson’s disease (PD) is characterised by rare high penetrance pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a significant minority in PD cases and high frequency, low penetrance variants, which contribute a small increase of the risk of developing sporadic PD. This knowledge has the potential to have a major impact in the clinical care of people with PD. We summarise these genetic influences and discuss the implications for therapeutics and clinical trial design.</jats:p>

dc.format.extent1006-1006
dc.format.mediumElectronic
dc.languageen
dc.language.isoen
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectParkinson's disease
dc.subjectgenetics
dc.subjectprecision medicine
dc.subjectclinical trials
dc.subjectmonogenic
dc.subjectpolygenic
dc.titleThe Genetics of Parkinson’s Disease and Implications for Clinical Practice
dc.typejournal-article
dc.typeReview
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/34208795
plymouth.issue7
plymouth.volume12
plymouth.publisher-urlhttp://dx.doi.org/10.3390/genes12071006
plymouth.publication-statusPublished online
plymouth.journalGenes
dc.identifier.doi10.3390/genes12071006
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/FoH - Applied Parkinson's Research
plymouth.organisational-group/Plymouth/Research Groups/FoH - Community and Primary Care
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
plymouth.organisational-group/Plymouth/Users by role/Researchers in ResearchFish submission
dc.publisher.placeSwitzerland
dcterms.dateAccepted2021-06-28
dc.rights.embargodate2021-7-6
dc.identifier.eissn2073-4425
dc.rights.embargoperiodNot known
rioxxterms.funderNational Institute for Health Research
rioxxterms.identifier.projectNIHR Academic Clinical Fellowship
rioxxterms.versionofrecord10.3390/genes12071006
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2021-06-30
rioxxterms.typeJournal Article/Review
plymouth.funderNIHR Academic Clinical Fellowship::National Institute for Health Research


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