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dc.contributor.authorPerera, Ben
dc.contributor.authorChen, Jen
dc.contributor.authorKorb, Len
dc.contributor.authorBorakati, Aen
dc.contributor.authorCourtenay, Ken
dc.contributor.authorHenley, Wen
dc.contributor.authorTromans, Sen
dc.contributor.authorShankar, Ren
dc.date.accessioned2021-05-22T18:49:57Z
dc.date.available2021-05-22T18:49:57Z
dc.date.issued2021-06en
dc.identifier.urihttp://hdl.handle.net/10026.1/17165
dc.description.abstract

Background: Attention-deficit hyperactivity disorder (ADHD) is higher in people with intellectual disability (ID) compared to the general population. Available limited evidence suggests this population has increased psychological problems, diagnostic overshadowing and psychotropic prescribing. This audit Identifies and analyzes real-world characteristics, diagnostic practices, treatment, and management of ADHD in adults with ID.Research Design and Methods: Pooled retrospective case note data for people with ID and ADHD, collected from 30 organizations across the UK, were analyzed. Patients were classified into mild and moderate-profound ID groups. Associated mental health and neurodevelopmental co-morbidity, Demographics, concomitant psychotropics, and mental and behavioral concerns were collected. Group differences were reported using logistic regression models.Results: Of 445 participants, 73% had co-occurring autism spectrum disorder (ASD) and 65% were prescribed ADHD medications. Those on ADHD medication were less likely to be prescribed antipsychotics (p < 0.001) and antidepressants (p < 0.001). Multiple significant differences were found in ADHD medication response between ID groups and those with/without co-morbid ASD but not associated with challenging behavior reduction.Conclusions: High levels of neurodevelopmental and psychiatric comorbidity were found. ID severity and the presence of ASD appear to influence the use of certain psychotropic medications. Appropriate use of ADHD medication appears to reduce psychotropic polypharmacy.

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dc.format.extent1071 - 1078en
dc.languageengen
dc.language.isoengen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectADHDen
dc.subjectIntellectual disabilityen
dc.subjectantidepressantsen
dc.subjectantipsychoticsen
dc.subjectautism spectrum disorderen
dc.subjectstompen
dc.subjectAdulten
dc.subjectAttention Deficit Disorder with Hyperactivityen
dc.subjectAutism Spectrum Disorderen
dc.subjectComorbidityen
dc.subjectCross-Sectional Studiesen
dc.subjectHumansen
dc.subjectIntellectual Disabilityen
dc.subjectPsychopharmacologyen
dc.subjectRetrospective Studiesen
dc.subjectUnited Kingdomen
dc.titlePatterns of comorbidity and psychopharmacology in adults with intellectual disability and attention deficit hyperactivity disorder: an UK national cross-sectional audit.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/33487043en
plymouth.issue8en
plymouth.volume22en
plymouth.publication-statusPublisheden
plymouth.journalExpert Opin Pharmacotheren
dc.identifier.doi10.1080/14656566.2021.1876028en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Users by role
dc.publisher.placeEnglanden
dc.identifier.eissn1744-7666en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1080/14656566.2021.1876028en
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.typeJournal Article/Reviewen


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