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dc.contributor.authorMartin, DSen
dc.contributor.authorMcNeil, Men
dc.contributor.authorBrew-Graves, Cen
dc.contributor.authorFilipe, Hen
dc.contributor.authorO’Driscoll, Ren
dc.contributor.authorStevens, JLen
dc.contributor.authorBurnish, Ren
dc.contributor.authorCumpstey, AFen
dc.contributor.authorWilliams, NRen
dc.contributor.authorMythen, MGen
dc.contributor.authorGrocott, MPWen

Background: Despite oxygen being the commonest drug administered to critically ill patients we do not know which oxygen saturation (SpO ) target results in optimal survival outcomes in those receiving mechanical ventilation. We therefore conducted a feasibility randomised controlled trial in the United Kingdom (UK) to assess whether it would be possible to host a larger national multi-centre trial to evaluate oxygenation targets in mechanically ventilated patients. Methods: We set out to recruit 60 participants across two sites into a trial in which they were randomised to receive conservative oxygenation (SpO 88–92%) or usual care (control – SpO ≥96%). The primary outcome was feasibility; factors related to safety and clinical outcomes were also assessed. Results: A total of 34 patients were recruited into the study until it was stopped due to time constraints. A number of key barriers to success were identified during the course of the study. The conservative oxygenation intervention was feasible and appeared to be safe in this small patient cohort and it achieved wide separation of the median time-weighted average (IQR) SpO at 91% (90–92%) in conservative oxygenation group versus 97% (96–97%) in control group. Conclusion: Whilst conservative oxygenation was a feasible and safe intervention which achieved clear group separation in oxygenation levels, the model used in this trial will require alterations to improve future participant recruitment rates in the UK. 2 2 2 2

dc.titleA feasibility randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patientsen
dc.typeJournal Article
plymouth.journalJournal of the Intensive Care Societyen
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.rights.embargoperiodNot knownen
rioxxterms.typeJournal Article/Reviewen

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