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dc.contributor.authorMartin, Daniel
dc.contributor.authorMcNeil, M
dc.contributor.authorBrew-Graves, C
dc.contributor.authorFilipe, H
dc.contributor.authorO’Driscoll, R
dc.contributor.authorStevens, Jia Liu
dc.contributor.authorBurnish, R
dc.contributor.authorCumpstey, AF
dc.contributor.authorWilliams, Norman
dc.contributor.authorMythen, MG
dc.contributor.authorGrocott, MPW
dc.date.accessioned2021-04-28T14:38:55Z
dc.date.available2021-04-28T14:38:55Z
dc.date.issued2021-11
dc.identifier.issn1751-1437
dc.identifier.issn2057-360X
dc.identifier.urihttp://hdl.handle.net/10026.1/17076
dc.description.abstract

<jats:sec><jats:title>Background</jats:title><jats:p> Despite oxygen being the commonest drug administered to critically ill patients we do not know which oxygen saturation (SpO<jats:sub>2</jats:sub>) target results in optimal survival outcomes in those receiving mechanical ventilation. We therefore conducted a feasibility randomised controlled trial in the United Kingdom (UK) to assess whether it would be possible to host a larger national multi-centre trial to evaluate oxygenation targets in mechanically ventilated patients. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> We set out to recruit 60 participants across two sites into a trial in which they were randomised to receive conservative oxygenation (SpO<jats:sub>2</jats:sub> 88–92%) or usual care (control – SpO<jats:sub>2</jats:sub> ≥96%). The primary outcome was feasibility; factors related to safety and clinical outcomes were also assessed. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> A total of 34 patients were recruited into the study until it was stopped due to time constraints. A number of key barriers to success were identified during the course of the study. The conservative oxygenation intervention was feasible and appeared to be safe in this small patient cohort and it achieved wide separation of the median time-weighted average (IQR) SpO<jats:sub>2</jats:sub> at 91% (90–92%) in conservative oxygenation group versus 97% (96–97%) in control group. </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Whilst conservative oxygenation was a feasible and safe intervention which achieved clear group separation in oxygenation levels, the model used in this trial will require alterations to improve future participant recruitment rates in the UK. </jats:p></jats:sec>

dc.format.extent280-287
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoeng
dc.publisherSAGE Publications
dc.subjectOxygen
dc.subjectcritical illness
dc.subjecthypoxaemia
dc.subjectintensive care
dc.subjectmechanical ventilation
dc.titleA feasibility randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients
dc.typejournal-article
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/35154365
plymouth.issue4
plymouth.volume22
plymouth.publication-statusPublished
plymouth.journalJournal of the Intensive Care Society
dc.identifier.doi10.1177/17511437211010031
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeEngland
dc.identifier.eissn2057-360X
dc.rights.embargoperiodNot known
rioxxterms.funderNational Institute for Health Research
rioxxterms.identifier.projectTargeted oxygen therapy in mechanically ventilated critically ill patients
rioxxterms.versionofrecord10.1177/17511437211010031
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
plymouth.funderTargeted oxygen therapy in mechanically ventilated critically ill patients::National Institute for Health Research


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