Association of Diabetes in Pregnancy with Child Weight at Birth, Age 12 Months and 5 Years – A Population-Based Electronic Cohort Study
dc.contributor.author | Morgan, K | |
dc.contributor.author | Rahman, M | |
dc.contributor.author | Atkinson, M | |
dc.contributor.author | Zhou, Shang-Ming | |
dc.contributor.author | Hill, R | |
dc.contributor.author | Khanom, A | |
dc.contributor.author | Paranjothy, S | |
dc.contributor.author | Brophy, S | |
dc.date.accessioned | 2021-02-04T22:20:40Z | |
dc.date.available | 2021-02-04T22:20:40Z | |
dc.date.issued | 2013-11-13 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.other | ARTN e79803 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/16851 | |
dc.description.abstract |
BACKGROUND: This study examines the effect of diabetes in pregnancy on offspring weight at birth and ages 1 and 5 years. METHODS: A population-based electronic cohort study using routinely collected linked healthcare data. Electronic medical records provided maternal diabetes status and offspring weight at birth and ages 1 and 5 years (n = 147,773 mother child pairs). Logistic regression models were used to obtain odds ratios to describe the association between maternal diabetes status and offspring size, adjusted for maternal pre-pregnancy weight, age and smoking status. FINDINGS: We identified 1,250 (0.9%) pregnancies with existing diabetes (27.8% with type 1 diabetes), 1,358 with gestational diabetes (0.9%) and 635 (0.4%) who developed diabetes post-pregnancy. Children whose mothers had existing diabetes were less likely to be large at 12 months (OR: 0.7 (95%CI: 0.6, 0.8)) than those without diabetes. Maternal diabetes was associated with high weight at age 5 years in children whose mothers had a high pre-pregnancy weight tertile (gestational diabetes, (OR:2.1 (95%CI:1.25-3.6)), existing diabetes (OR:1.3 (95%CI:1.0 to 1.6)). CONCLUSION: The prevention of childhood obesity should focus on mothers with diabetes with a high maternal pre-pregnancy weight. We found little evidence that diabetes in pregnancy leads to long term obesity 'programming'. | |
dc.format.extent | e79803-e79803 | |
dc.format.medium | Electronic-eCollection | |
dc.language | en | |
dc.language.iso | eng | |
dc.publisher | Public Library of Science (PLoS) | |
dc.subject | Birth Weight | |
dc.subject | Body Weight | |
dc.subject | Child, Preschool | |
dc.subject | Cohort Studies | |
dc.subject | Diabetes, Gestational | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Infant | |
dc.subject | Infant, Newborn | |
dc.subject | Male | |
dc.subject | Odds Ratio | |
dc.subject | Pediatric Obesity | |
dc.subject | Population Surveillance | |
dc.subject | Pregnancy | |
dc.subject | Prevalence | |
dc.subject | Risk Factors | |
dc.subject | Weight Gain | |
dc.title | Association of Diabetes in Pregnancy with Child Weight at Birth, Age 12 Months and 5 Years – A Population-Based Electronic Cohort Study | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Research Support, Non-U.S. Gov't | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000327254700160&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 11 | |
plymouth.volume | 8 | |
plymouth.publication-status | Published online | |
plymouth.journal | PLoS ONE | |
dc.identifier.doi | 10.1371/journal.pone.0079803 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/School of Nursing and Midwifery | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2013-10-04 | |
dc.identifier.eissn | 1932-6203 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1371/journal.pone.0079803 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2013 | |
rioxxterms.type | Journal Article/Review |