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dc.contributor.authorMorgan, Ken
dc.contributor.authorRahman, Men
dc.contributor.authorAtkinson, Men
dc.contributor.authorZhou, S-Men
dc.contributor.authorHill, Ren
dc.contributor.authorKhanom, Aen
dc.contributor.authorParanjothy, Sen
dc.contributor.authorBrophy, Sen
dc.date.accessioned2021-02-04T22:20:40Z
dc.date.available2021-02-04T22:20:40Z
dc.date.issued2013en
dc.identifier.urihttp://hdl.handle.net/10026.1/16851
dc.description.abstract

BACKGROUND: This study examines the effect of diabetes in pregnancy on offspring weight at birth and ages 1 and 5 years. METHODS: A population-based electronic cohort study using routinely collected linked healthcare data. Electronic medical records provided maternal diabetes status and offspring weight at birth and ages 1 and 5 years (n = 147,773 mother child pairs). Logistic regression models were used to obtain odds ratios to describe the association between maternal diabetes status and offspring size, adjusted for maternal pre-pregnancy weight, age and smoking status. FINDINGS: We identified 1,250 (0.9%) pregnancies with existing diabetes (27.8% with type 1 diabetes), 1,358 with gestational diabetes (0.9%) and 635 (0.4%) who developed diabetes post-pregnancy. Children whose mothers had existing diabetes were less likely to be large at 12 months (OR: 0.7 (95%CI: 0.6, 0.8)) than those without diabetes. Maternal diabetes was associated with high weight at age 5 years in children whose mothers had a high pre-pregnancy weight tertile (gestational diabetes, (OR:2.1 (95%CI:1.25-3.6)), existing diabetes (OR:1.3 (95%CI:1.0 to 1.6)). CONCLUSION: The prevention of childhood obesity should focus on mothers with diabetes with a high maternal pre-pregnancy weight. We found little evidence that diabetes in pregnancy leads to long term obesity 'programming'.

en
dc.format.extente79803 - ?en
dc.languageengen
dc.language.isoengen
dc.subjectBirth Weighten
dc.subjectBody Weighten
dc.subjectChild, Preschoolen
dc.subjectCohort Studiesen
dc.subjectDiabetes, Gestationalen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectInfanten
dc.subjectInfant, Newbornen
dc.subjectMaleen
dc.subjectOdds Ratioen
dc.subjectPediatric Obesityen
dc.subjectPopulation Surveillanceen
dc.subjectPregnancyen
dc.subjectPrevalenceen
dc.subjectRisk Factorsen
dc.subjectWeight Gainen
dc.titleAssociation of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/24236160en
plymouth.issue11en
plymouth.volume8en
plymouth.publication-statusPublished onlineen
plymouth.journalPLoS Oneen
dc.identifier.doi10.1371/journal.pone.0079803en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Nursing and Midwifery
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeUnited Statesen
dcterms.dateAccepted2013-10-04en
dc.identifier.eissn1932-6203en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1371/journal.pone.0079803en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2013en
rioxxterms.typeJournal Article/Reviewen


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