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dc.contributor.authorStevens, JL
dc.contributor.authorFeelisch, M
dc.contributor.authorMartin, Daniel
dc.date.accessioned2020-10-16T12:57:19Z
dc.date.available2020-10-16T12:57:19Z
dc.date.issued2019-12
dc.identifier.issn0003-2999
dc.identifier.issn1526-7598
dc.identifier.urihttp://hdl.handle.net/10026.1/16548
dc.description.abstract

<jats:p>Reactive oxygen species (ROS) are essential for cellular signaling and physiological function. An imbalance between ROS production and antioxidant protection results in a state of oxidative stress (OS), which is associated with perturbations in reduction/oxidation (redox) regulation, cellular dysfunction, organ failure, and disease. The pathophysiology of OS is closely interlinked with inflammation, mitochondrial dysfunction, and, in the case of surgery, ischemia/reperfusion injury (IRI). Perioperative OS is a complex response that involves patient, surgical, and anesthetic factors. The magnitude of tissue injury inflicted by the surgery affects the degree of OS, and both duration and nature of the anesthetic procedure applied can modify this. Moreover, the interindividual susceptibility to the impact of OS is likely to be highly variable and potentially linked to underlying comorbidities. The pathological link between OS and postoperative complications remains unclear, in part due to the complexities of measuring ROS- and OS-mediated damage. Exogenous antioxidant use and exercise have been shown to modulate OS and may have potential as countermeasures to improve postoperative recovery. A better understanding of the underlying mechanisms of OS, redox signaling, and regulation can provide an opportunity for patient-specific phenotyping and development of targeted interventions to reduce the disruption that surgery can cause to our physiology. Anesthesiologists are in a unique position to deliver countermeasures to OS and improve physiological resilience. To shy away from a process so fundamental to the welfare of these patients would be foolhardy and negligent, thus calling for an improved understanding of this complex facet of human biology.</jats:p>

dc.format.extent1749-1760
dc.format.mediumPrint
dc.languageen
dc.language.isoeng
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.subjectAntioxidants
dc.subjectExercise
dc.subjectHumans
dc.subjectOxidative Stress
dc.subjectPerioperative Care
dc.subjectPostoperative Complications
dc.subjectReactive Oxygen Species
dc.titlePerioperative Oxidative Stress: The Unseen Enemy
dc.typejournal-article
dc.typeJournal Article
dc.typeReview
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000496924900056&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue6
plymouth.volume129
plymouth.publication-statusPublished
plymouth.journalAnesthesia &amp; Analgesia
dc.identifier.doi10.1213/ane.0000000000004455
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeUnited States
dc.identifier.eissn1526-7598
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1213/ane.0000000000004455
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review


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