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dc.contributor.authorComber, Sean
dc.contributor.authorUpton, Mathew
dc.contributor.authorLewin, S
dc.contributor.authorPowell, N
dc.contributor.authorHutchinson, Tom
dc.date.accessioned2020-10-08T10:47:44Z
dc.date.issued2020-08-12
dc.identifier.issn0305-7453
dc.identifier.issn1460-2091
dc.identifier.urihttp://hdl.handle.net/10026.1/16493
dc.description.abstract

There is growing interest in the role of secondary bacterial and fungal infections as a cause of increased morbidity and mortality in COVID-19 patients,1 with reports of up to 95% of COVID-19 inpatients being prescribed antibiotics.2 Concerns have been raised over the environmental implications of such a large-scale drug administration3 and statements made about the potential impacts of COVID-19-related antibiotic prescription on antimicrobial resistance (AMR) and other toxicological effects on the environment.4 The UK National Strategy aims for a world in which AMR is effectively contained, controlled and mitigated by 2040.5 Taking a ‘One Health’ approach to effective stewardship in settings such as those being experienced in the current pandemic will be key to minimizing the negative impacts of antibiotic use. A large proportion of some drugs (and metabolites) are excreted by patients into wastewater treatment works (WwTW), leading to release of drug residues into effluent-receiving rivers and coastal waters. Environmental concentrations and impacts will be greatest where drugs are used in high volumes, pass through WwTW largely undegraded and are discharged into rivers with limited dilution.

dc.format.extent3411-3412
dc.format.mediumPrint
dc.languageen
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectAnti-Bacterial Agents
dc.subjectBetacoronavirus
dc.subjectCOVID-19
dc.subjectCoronavirus Infections
dc.subjectDrug Resistance, Bacterial
dc.subjectEnvironmental Pollutants
dc.subjectHumans
dc.subjectOne Health
dc.subjectPandemics
dc.subjectPneumonia, Viral
dc.subjectRisk Assessment
dc.subjectSARS-CoV-2
dc.subjectUnited Kingdom
dc.subjectWater Pollutants, Chemical
dc.titleCOVID-19, antibiotics and One Health: a UK environmental risk assessment
dc.typejournal-article
dc.typeJournal Article
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000593065400048&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue11
plymouth.volume75
plymouth.publication-statusPublished
plymouth.journalJournal of Antimicrobial Chemotherapy
dc.identifier.doi10.1093/jac/dkaa338
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Biomedical Sciences
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Geography, Earth and Environmental Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA06 Agriculture, Veterinary and Food Science
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/BEACh
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
plymouth.organisational-group/Plymouth/Research Groups/Marine Institute
plymouth.organisational-group/Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR)
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
plymouth.organisational-group/Plymouth/Users by role/Researchers in ResearchFish submission
dc.publisher.placeEngland
dcterms.dateAccepted2020-07-15
dc.rights.embargodate2020-10-14
dc.identifier.eissn1460-2091
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1093/jac/dkaa338
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
rioxxterms.licenseref.startdate2020-08-12
rioxxterms.typeJournal Article/Review


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