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dc.contributor.authorAhmad Demerchi, S
dc.contributor.authorRobert McFarlane, J
dc.contributor.authorDominique Jean Moens, P
dc.contributor.authorKing, N
dc.date.accessioned2020-09-28T10:25:39Z
dc.date.available2020-09-28T10:25:39Z
dc.date.issued2020-03-23
dc.identifier.issn2329-0870
dc.identifier.urihttp://hdl.handle.net/10026.1/16433
dc.description.abstract

Homocysteine (Hcy) is a critical indicator of cardiovascular disease. High levels of Hcy have now been recognised as a risk factor for the development of a wide range of diseases. Hyperhomocysteinemia (Hhcy) can be induced by methionine or Hcy supplementation. On the other hand, Glutathione (GSH) is a major antioxidant in the body and also an important compound for oxidative defence. It is composed of 3 amino acids: cysteine, glutamate, and glycine. Interestingly, methionine is also a crucial compound in GSH synthesis. This study aims to assess the impact of 1% L-methionine feeding (10 or 30 weeks) on the body weight and serum Hcy and GSH levels of young adult (16 weeks) and middle-aged (36 weeks) Wistar rats of both sexes. Serum was analysed for Hcy and reduced GSH levels by liquid chromatography mass spectrometry (LCMS) in response to 1% L-methionine feeding. One percent L-methionine feeding decreased body weight in all conditions investigated, although this only reached significance in males after 10 weeks supplementation and females after 30 weeks supplementation. It also induced a significant increase in the serum Hcy levels of male Wistar rats, whilst having no significant effect on Hcy serum levels in female rats. Finally, we also observed a small increase in serum GSH levels in female Wistar rats but no change in serum GSH levels in the males. These results suggest that methionine feeding affects body weight homeostasis and alters by products of methionine catabolism.

dc.format.extent21-21
dc.languageen
dc.language.isoen
dc.publisherScience Publishing Group
dc.titleEffect of L-Methionine Feeding on Serum Homocysteine and Glutathione Levels in Male and Female Wistar Rats
dc.typejournal-article
plymouth.issue1
plymouth.volume8
plymouth.publication-statusPublished
plymouth.journalAdvances in Biochemistry
dc.identifier.doi10.11648/j.ab.20200801.14
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dcterms.dateAccepted2020-03-10
dc.rights.embargodate2020-9-29
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.11648/j.ab.20200801.14
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-03-23
rioxxterms.typeJournal Article/Review


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