Clinical detection of neurodegenerative blood biomarkers using graphene immunosensor
dc.contributor.author | Li, B | |
dc.contributor.author | Tan, H | |
dc.contributor.author | Jenkins, David | |
dc.contributor.author | Srinivasa Raghavan, V | |
dc.contributor.author | Rosa, BG | |
dc.contributor.author | Güder, F | |
dc.contributor.author | Pan, Genhua | |
dc.contributor.author | Yeatman, E | |
dc.contributor.author | Sharp, DJ | |
dc.date.accessioned | 2020-09-11T11:22:40Z | |
dc.date.available | 2020-09-11T11:22:40Z | |
dc.date.issued | 2020-10-30 | |
dc.identifier.issn | 0008-6223 | |
dc.identifier.issn | 1873-3891 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/16240 | |
dc.description.abstract |
Accurate detection of blood biomarkers related to neurodegenerative diseases could provide a shortcut to identifying early stage patients before the onset of symptoms. The specificity, selectivity and operational requirements of the current technologies, however, preclude their use in the primary clinical setting for early detection. Graphene, an emerging 2D nanomaterial, is a promising candidate for biosensing which has the potential to meet the performance requirements and enable cost-effective, portable and rapid diagnosis. In this review, we compare graphene-based immunosensing technologies with conventional enzyme-linked immunosorbent assays and cutting-edge single molecule array techniques for the detection of blood-based neurodegenerative biomarkers. We cover the progress in electrical, electrochemical and optical graphene-based immunosensors and outline the barriers that slow or prevent the adoption of this emerging technology in primary clinical settings. We also highlight the possible solutions to overcome these barriers with an outlook on the future of the promising, graphene immunosensor technology. | |
dc.format.extent | 144-162 | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Elsevier BV | |
dc.subject | Graphene | |
dc.subject | Clinical detection | |
dc.subject | Neurodegenerative disease | |
dc.subject | Protein biomarkers | |
dc.subject | Immunosensor | |
dc.title | Clinical detection of neurodegenerative blood biomarkers using graphene immunosensor | |
dc.type | journal-article | |
dc.type | Review | |
dc.type | Journal | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000565900900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.volume | 168 | |
plymouth.publication-status | Published | |
plymouth.journal | Carbon | |
dc.identifier.doi | 10.1016/j.carbon.2020.06.048 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Science and Engineering | |
plymouth.organisational-group | /Plymouth/Faculty of Science and Engineering/School of Engineering, Computing and Mathematics | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA12 Engineering | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dcterms.dateAccepted | 2020-06-15 | |
dc.rights.embargodate | 2023-4-15 | |
dc.identifier.eissn | 1873-3891 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1016/j.carbon.2020.06.048 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2020-10-30 | |
rioxxterms.type | Journal Article/Review |