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dc.contributor.authorHughes, SWen
dc.contributor.authorBasra, Men
dc.contributor.authorChan, Cen
dc.contributor.authorParr, Cen
dc.contributor.authorWong, Fen
dc.contributor.authorGomes, Sen
dc.contributor.authorStrutton, PHen
dc.date.accessioned2020-07-29T12:46:30Z
dc.date.available2020-07-29T12:46:30Z
dc.date.issued2020-04-26en
dc.identifier.issn1526-2375en
dc.identifier.urihttp://hdl.handle.net/10026.1/16121
dc.description.abstract

<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Objectives</jats:title> <jats:p>Areas of secondary hyperalgesia can be assessed using quantitative sensory testing (QST). Delivering noxious electrocutaneous stimulation could provide added benefit by allowing multiple measurements of the magnitude of hyperalgesia. We aimed to characterize the use of electrical pain perception (EPP) thresholds alongside QST as a means by which to measure changes in pain thresholds within an area of secondary mechanical hyperalgesia.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>EPP and heat pain thresholds (HPTs) were measured at five distinct points at baseline and following 1% capsaicin cream application, one within a central zone and four within a secondary zone. Areas of secondary mechanical hyperalgesia were mapped using QST. In a further 14 participants, capsaicin-induced reduction in EPP thresholds was mapped using a radial lines approach across 24 points.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>There was a reduction in EPP threshold measured at the four points within the secondary zone, which was within the mapped area of mechanical secondary hyperalgesia. The magnitude of secondary hyperalgesia could be split into a mild (∼4% reduction) and severe (∼21% reduction) area within an individual subject. There was no reduction in HPT within the secondary zone, but there was a reduction in both HPT and EPP threshold within the primary zone. EPP mapping revealed differences in the magnitude and spread of hyperalgesia across all subjects.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Measuring capsaicin-induced reduction in EPP thresholds can be used to map hyperalgesic areas in humans. This semi-automated approach allows rapid assessment of the magnitude of hyperalgesia, both within an individual subject and across a study population.</jats:p> </jats:sec>

en
dc.languageenen
dc.language.isoenen
dc.publisherOxford University Press (OUP)en
dc.titleCapsaicin-Induced Changes in Electrical Pain Perception Threshold Can Be Used to Assess the Magnitude of Secondary Hyperalgesia in Humansen
dc.typeJournal Article
plymouth.journalPain Medicineen
dc.identifier.doi10.1093/pm/pnaa082en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Psychology
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA04 Psychology, Psychiatry and Neuroscience
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA04 Psychology, Psychiatry and Neuroscience/UoA04 Psychology, Psychiatry and Neuroscience MANUAL
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dcterms.dateAccepted2020-02-25en
dc.rights.embargodate2021-04-26en
dc.identifier.eissn1526-4637en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1093/pm/pnaa082en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-04-26en
rioxxterms.typeJournal Article/Reviewen


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