Trace element deficiency is highly prevalent and associated with infection and mortality in patients with alcoholic hepatitis
dc.contributor.author | Dhanda, Ashwin | |
dc.contributor.author | Atkinson, S | |
dc.contributor.author | Vergis, N | |
dc.contributor.author | Enki, D | |
dc.contributor.author | EKİM DERTLİ, Samiye | |
dc.contributor.author | Clough, Robert | |
dc.contributor.author | Cramp, Matthew | |
dc.contributor.author | Thursz, M | |
dc.date.accessioned | 2020-07-09T13:55:45Z | |
dc.date.issued | 2020-06-23 | |
dc.identifier.issn | 0269-2813 | |
dc.identifier.issn | 1365-2036 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/15950 | |
dc.description.abstract |
<jats:title>Summary</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Malnutrition is common in patients with alcohol‐related liver disease and is associated with outcome in patients with alcoholic hepatitis. Trace elements (cobalt, copper, iron, selenium and zinc) are micronutrients essential for many cellular processes including antioxidant pathways. The prevalence and relevance of trace element deficiency is unknown in alcoholic hepatitis.</jats:p></jats:sec><jats:sec><jats:title>Aim</jats:title><jats:p>To determine the prevalence of trace element deficiency and its association with clinical outcomes in patients with alcoholic hepatitis.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Serum was obtained from patients with alcoholic hepatitis, alcohol‐related cirrhosis and healthy volunteers as part of clinical trials, cohort studies and a biobank. Trace element concentration was measured by inductively coupled plasma mass spectrometry. Association of trace element levels with development of infection within 90 days and mortality within 28 and 90 days was evaluated by multivariate logistic regression.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Sera from 302 patients with alcoholic hepatitis, 46 with alcohol‐related cirrhosis and 15 healthy controls were analysed for trace element concentration. The prevalence of zinc deficiency (85%) and selenium deficiency (67%) in alcoholic hepatitis was higher than in alcohol‐related cirrhosis (72% [p=0.04] and 37% [p<0.001], respectively). Zinc, selenium, copper and chromium were significantly different between groups. Iron deficiency was a predictor of development of infection within 90 days. Zinc deficiency was a predictor of mortality within 28 and 90 days.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Trace element deficiency in patients with alcoholic hepatitis is highly prevalent and associated with infection and mortality. Supplementation with selected trace elements may improve clinical outcomes in this patient group but further insight is required of their biological and clinical effects.</jats:p></jats:sec> | |
dc.format.extent | 537-544 | |
dc.format.medium | Print-Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Wiley | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Female | |
dc.subject | Hepatitis, Alcoholic | |
dc.subject | Humans | |
dc.subject | Infections | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Prevalence | |
dc.subject | Trace Elements | |
dc.subject | Young Adult | |
dc.title | Trace element deficiency is highly prevalent and associated with infection and mortality in patients with alcoholic hepatitis | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Research Support, Non-U.S. Gov't | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000541820400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 3 | |
plymouth.volume | 52 | |
plymouth.publication-status | Published | |
plymouth.journal | Alimentary Pharmacology & Therapeutics | |
dc.identifier.doi | 10.1111/apt.15880 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
plymouth.organisational-group | /Plymouth/Faculty of Science and Engineering | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/BEACh | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR) | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | England | |
dcterms.dateAccepted | 2020-05-22 | |
dc.rights.embargodate | 2021-6-23 | |
dc.identifier.eissn | 1365-2036 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.funder | Medical Research Council | |
rioxxterms.identifier.project | MICA: Minimising Mortality from Alcoholic Hepatitis | |
rioxxterms.versionofrecord | 10.1111/apt.15880 | |
rioxxterms.licenseref.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
rioxxterms.licenseref.startdate | 2020-06-23 | |
rioxxterms.type | Journal Article/Review | |
plymouth.funder | MICA: Minimising Mortality from Alcoholic Hepatitis::Medical Research Council |