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dc.contributor.authorMartin, DSen
dc.contributor.authorBrew-Graves, Cen
dc.contributor.authorMcCartan, Nen
dc.contributor.authorJell, Gen
dc.contributor.authorPotyka, Ien
dc.contributor.authorStevens, Jen
dc.contributor.authorWilliams, NRen
dc.contributor.authorMcNeil, Men
dc.contributor.authorO’Driscoll, BRen
dc.contributor.authorMythen, Men
dc.contributor.authorGrocott, MPWen

<jats:sec><jats:title>Introduction</jats:title><jats:p>Oxygen is the most commonly administered drug to mechanically ventilated critically ill adults, yet little is known about the optimum oxygen saturation (SpO<jats:sub>2</jats:sub>) target for these patients; the current standard of care is an SpO<jats:sub>2</jats:sub>of 96% or above. Small pilot studies have demonstrated that permissive hypoxaemia (aiming for a lower SpO<jats:sub>2</jats:sub>than normal by using a lower fractional inspired oxygen concentration (FIO<jats:sub>2</jats:sub>)) can be achieved in the critically ill and appears to be safe. This approach has not been evaluated in a National Health Service setting. It is possible that permissive hypoxaemia may be beneficial to critically ill patients thus it requires robust evaluation.</jats:p></jats:sec><jats:sec><jats:title>Methods and analysis</jats:title><jats:p>Targeted OXygen therapY in Critical illness (TOXYC) is a feasibility randomised controlled trial (RCT) to evaluate whether recruiting patients to a study of permissive hypoxaemia is possible in the UK. It will also investigate biological mechanisms that may underlie the links between oxygenation and patient outcomes. Mechanically ventilated patients with respiratory failure will be recruited from critical care units at two sites and randomised (1:1 ratio) to an SpO<jats:sub>2</jats:sub>target of either 88%–92% or ≥96% while intubated with an endotracheal tube. Clinical teams can adjust FIO<jats:sub>2</jats:sub>and ventilator settings as they wish to achieve these targets. Clinical information will be collected before, during and after the intervention and blood samples taken to measure markers of systemic oxidative stress. The primary outcome of this study is feasibility, which will be assessed by recruitment rate, protocol adherence and withdrawal rates. Secondary outcomes will include a comparison of standard critical care outcome measures between the two intervention groups, and the measurement of biomarkers of systemic oxidative stress. The results will be used to calculate a sample size, likely number of sites and overall length of time required for a subsequent large multicentre RCT.</jats:p></jats:sec><jats:sec><jats:title>Ethics and dissemination</jats:title><jats:p>This study was approved by the London - Harrow Research Ethics Committee on 2 November 2017 (REC Reference 17/LO/1334) and received HRA approval on 13 November 2017. Results from this study will be disseminated in peer-reviewed journals, at medical and scientific meetings, in the NIHR Journals Library and patient information websites.</jats:p></jats:sec><jats:sec><jats:title>Trial registration number</jats:title><jats:p><jats:ext-link xmlns:xlink="" xlink:href="NCT03287466" ext-link-type="clintrialgov" specific-use="clinicaltrial pre-results">NCT03287466</jats:ext-link>; Pre-results.</jats:p></jats:sec>

dc.format.extente021674 - e021674en
dc.titleProtocol for a feasibility randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patientsen
dc.typeJournal Article
plymouth.journalBMJ Openen
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.rights.embargoperiodNot knownen
rioxxterms.typeJournal Article/Reviewen

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