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dc.contributor.authorBescos, R
dc.contributor.authorAshworth, A
dc.contributor.authorCutler, C
dc.contributor.authorBrookes, ZL
dc.contributor.authorBelfield, L
dc.contributor.authorRodiles, A
dc.contributor.authorCasas-Agustench, P
dc.contributor.authorFarnham, G
dc.contributor.authorLiddle, L
dc.contributor.authorBurleigh, M
dc.contributor.authorWhite, D
dc.contributor.authorEaston, C
dc.contributor.authorHickson, M
dc.date.accessioned2020-05-13T16:35:30Z
dc.date.issued2020-12
dc.identifier.issn2045-2322
dc.identifier.issn2045-2322
dc.identifier.other5254
dc.identifier.urihttp://hdl.handle.net/10026.1/15682
dc.description.abstract

Following a single blind, cross-over and non-randomized design we investigated the effect of 7-day use of chlorhexidine (CHX) mouthwash on the salivary microbiome as well as several saliva and plasma biomarkers in 36 healthy individuals. They rinsed their mouth (for 1 min) twice a day for seven days with a placebo mouthwash and then repeated this protocol with CHX mouthwash for a further seven days. Saliva and blood samples were taken at the end of each treatment to analyse the abundance and diversity of oral bacteria, and pH, lactate, glucose, nitrate and nitrite concentrations. CHX significantly increased the abundance of Firmicutes and Proteobacteria, and reduced the content of Bacteroidetes, TM7, SR1 and Fusobacteria. This shift was associated with a significant decrease in saliva pH and buffering capacity, accompanied by an increase in saliva lactate and glucose levels. Lower saliva and plasma nitrite concentrations were found after using CHX, followed by a trend of increased systolic blood pressure. Overall, this study demonstrates that mouthwash containing CHX is associated with a major shift in the salivary microbiome, leading to more acidic conditions and lower nitrite availability in healthy individuals.

dc.format.extent0-0
dc.format.mediumElectronic
dc.languageen
dc.language.isoen
dc.publisherSpringer Science and Business Media LLC
dc.subjectAdult
dc.subjectBiomarkers
dc.subjectBlood Pressure
dc.subjectChlorhexidine
dc.subjectCross-Over Studies
dc.subjectFemale
dc.subjectGlucose
dc.subjectHumans
dc.subjectHydrogen-Ion Concentration
dc.subjectLactates
dc.subjectMale
dc.subjectMicrobiota
dc.subjectMouth
dc.subjectMouthwashes
dc.subjectNitrates
dc.subjectNitrites
dc.subjectSaliva
dc.subjectSingle-Blind Method
dc.subjectSpecies Specificity
dc.subjectYoung Adult
dc.titleEffects of Chlorhexidine mouthwash on the oral microbiome
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/32210245
plymouth.issue1
plymouth.volume10
plymouth.publisher-urlhttp://dx.doi.org/10.1038/s41598-020-61912-4
plymouth.publication-statusPublished online
plymouth.journalScientific Reports
dc.identifier.doi10.1038/s41598-020-61912-4
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Dental School
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
plymouth.declined2020-05-13T17:35:30.440+0100
dc.publisher.placeEngland
dcterms.dateAccepted2020-02-26
dc.rights.embargodate2020-6-6
dc.identifier.eissn2045-2322
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1038/s41598-020-61912-4
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-03-24
rioxxterms.typeJournal Article/Review


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