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dc.contributor.authorSneyd, JR
dc.date.accessioned2012-11-09T22:11:02Z
dc.date.accessioned2013-06-19T11:59:39Z
dc.date.available2012-11-09T22:11:02Z
dc.date.available2013-06-19T11:59:39Z
dc.date.issued2012-08
dc.identifier.issn0003-2999
dc.identifier.issn1526-7598
dc.identifier.urihttp://hdl.handle.net/10026.1/1539
dc.description.abstract

This edition of the journal includes two manuscripts describing the first human administration of remimazolam, a novel benzodiazepine. Not all such Phase 1 studies have a happy ending, the drop-out rate of development drugs is high and Phase 1 studies frequently represent the last outing for candidate compounds. Such investigations, together with early clinical studies also offer the editorialist an opportunity to pontificate (often wrongly) on the possible advantages of the new drug and to indulge in some speculation. Hence: “mivacurium may constitute a versatile new addition to anesthetic practice.” “minaxolone is a most promising induction agent…” and more accurately “midazolam would appear to offer many advantages over available benzodiazepines”.

dc.format.extent217-219
dc.format.mediumPrint
dc.languageen
dc.language.isoeng
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.relation.replaceshttp://hdl.handle.net/10026.1/1224
dc.relation.replaces10026.1/1224
dc.subjectBenzodiazepines
dc.subjectComputer Simulation
dc.subjectFemale
dc.subjectHumans
dc.subjectHypnotics and Sedatives
dc.subjectMale
dc.subjectMidazolam
dc.subjectModels, Biological
dc.titleRemimazolam: new beginnings or just a me-too?
dc.typejournal-article
dc.typeEditorial Material
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/22826518
plymouth.issue2
plymouth.volume115
plymouth.publisher-urlhttp://dx.doi.org/10.1213/ane.0b013e31823acb95
plymouth.publication-statusPublished
plymouth.journalAnesthesia & Analgesia
dc.identifier.doi10.1213/ane.0b013e31823acb95
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Users by role
dc.publisher.placeUnited States
dcterms.dateAccepted2012-01-01
dc.rights.embargodate2023-10-6
dc.identifier.eissn1526-7598
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1213/ane.0b013e31823acb95
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review


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