Distinct VIP and PACAP Functions in the Distal Nerve Stump During Peripheral Nerve Regeneration
dc.contributor.author | Zhang, He | |
dc.date.accessioned | 2019-12-12T10:31:46Z | |
dc.date.issued | 2019-12-12 | |
dc.identifier.issn | 1662-453X | |
dc.identifier.issn | 1662-453X | |
dc.identifier.other | ARTN 1326 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/15247 | |
dc.description.abstract |
Vasoactive Intestinal Peptide (VIP) and Pituitary Adenylyl Cyclase Activating Peptide (PACAP) are regeneration-associated neuropeptides, which are up-regulated by neurons following peripheral nerve injury. So far, they have only been studied for their roles as autocrine signals for both neuronal survival and axon outgrowth during peripheral nerve regeneration. In this report, we examined VIP and PACAP's paracrine effects on Schwann cells and macrophages in the distal nerve stump during peripheral nerve regeneration. We show that VPAC1, VPAC2, and PAC1 are all up-regulated in the mouse distal nerve following peripheral nerve injury and are highly expressed in Schwann cells and macrophages within the distal sciatic nerve. We further investigated the effect of VIP and PACAP on cultured rat Schwann cells, and found that VIP and PACAP can not only promote myelin gene expression in Schwann cells but can also inhibit the release of pro-inflammatory cytokines by Schwann cells. Furthermore, we show that VIP and PACAP inhibit the release of pro-inflammatory cytokines and enhance anti-inflammatory cytokine expression in sciatic nerve explants. Our results provide evidence that VIP and PACAP could have important functions in the distal nerve stump following injury to promote remyelination and regulate the inflammatory response. Thus, VIP and PACAP receptors appear as important targets to promote peripheral nerve repair following injury. | |
dc.format.extent | 1326- | |
dc.format.medium | Electronic-eCollection | |
dc.language | eng | |
dc.language.iso | en | |
dc.publisher | Frontiers Media | |
dc.subject | VIP and PACAP | |
dc.subject | receptor expression | |
dc.subject | Schwann cells | |
dc.subject | macrophages | |
dc.subject | remyelination | |
dc.subject | inflammatory cytokines | |
dc.title | Distinct VIP and PACAP Functions in the Distal Nerve Stump During Peripheral Nerve Regeneration | |
dc.type | journal-article | |
dc.type | Journal Article | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000504736900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.volume | 13 | |
plymouth.publication-status | Published online | |
plymouth.journal | Frontiers in Neuroscience | |
dc.identifier.doi | 10.3389/fnins.2019.01326 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | Switzerland | |
dcterms.dateAccepted | 2019-11-26 | |
dc.rights.embargodate | 2019-12-14 | |
dc.identifier.eissn | 1662-453X | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.3389/fnins.2019.01326 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2019-12-12 | |
rioxxterms.type | Journal Article/Review |