Show simple item record

dc.contributor.authorJamjoom, AAB
dc.contributor.authorJoannides, AJ
dc.contributor.authorPoon, Michael
dc.contributor.authorChari, A
dc.contributor.authorZaben, M
dc.contributor.authorAbdulla, MAH
dc.contributor.authorRoach, J
dc.contributor.authorGlancz, LJ
dc.contributor.authorSolth, A
dc.contributor.authorDuddy, J
dc.contributor.authorBrennan, PM
dc.contributor.authorBayston, R
dc.contributor.authorBulters, DO
dc.contributor.authorMallucci, CL
dc.contributor.authorJenkinson, MD
dc.contributor.authorGray, WP
dc.contributor.authorKandasamy, J
dc.contributor.authorHutchinson, PJ
dc.contributor.authorKolias, AG
dc.contributor.authorAhmed, AI
dc.date.accessioned2019-11-25T21:41:46Z
dc.date.available2019-11-25T21:41:46Z
dc.date.issued2018-02
dc.identifier.issn0022-3050
dc.identifier.issn1468-330X
dc.identifier.urihttp://hdl.handle.net/10026.1/15179
dc.description.abstract

<jats:sec><jats:title>Objectives</jats:title><jats:p>External ventricular drain (EVD) insertion is a common neurosurgical procedure. EVD-related infection (ERI) is a major complication that can lead to morbidity and mortality. In this study, we aimed to establish a national ERI rate in the UK and Ireland and determine key factors influencing the infection risk.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A prospective multicentre cohort study of EVD insertions in 21 neurosurgical units was performed over 6 months. The primary outcome measure was 30-day ERI. A Cox regression model was used for multivariate analysis to calculate HR.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 495 EVD catheters were inserted into 452 patients with EVDs remaining in situ for 4700 days (median 8 days; IQR 4–13). Of the catheters inserted, 188 (38%) were antibiotic-impregnated, 161 (32.5%) were plain and 146 (29.5%) were silver-bearing. A total of 46 ERIs occurred giving an infection risk of 9.3%. Cox regression analysis demonstrated that factors independently associated with increased infection risk included duration of EVD placement for ≥8 days (HR=2.47 (1.12–5.45); p=0.03), regular sampling (daily sampling (HR=4.73 (1.28–17.42), p=0.02) and alternate day sampling (HR=5.28 (2.25–12.38); p&lt;0.01). There was no association between catheter type or tunnelling distance and ERI.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>In the UK and Ireland, the ERI rate was 9.3% during the study period. The study demonstrated that EVDs left in situ for ≥8 days and those sampled more frequently were associated with a higher risk of infection. Importantly, the study showed no significant difference in ERI risk between different catheter types.</jats:p></jats:sec>

dc.format.extent120-126
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoeng
dc.publisherBMJ
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectCatheter-Related Infections
dc.subjectCatheters, Indwelling
dc.subjectCerebral Ventricles
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectHumans
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectIreland
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeurosurgical Procedures
dc.subjectPostoperative Complications
dc.subjectProportional Hazards Models
dc.subjectProspective Studies
dc.subjectStaphylococcal Infections
dc.subjectUnited Kingdom
dc.subjectVentriculostomy
dc.subjectYoung Adult
dc.titleProspective, multicentre study of external ventricular drainage-related infections in the UK and Ireland
dc.typejournal-article
dc.typeJournal Article
dc.typeMulticenter Study
dc.typeObservational Study
dc.typeResearch Support, Non-U.S. Gov't
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000424004400004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue2
plymouth.volume89
plymouth.publication-statusPublished
plymouth.journalJournal of Neurology, Neurosurgery &amp; Psychiatry
dc.identifier.doi10.1136/jnnp-2017-316415
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Users by role
dc.publisher.placeEngland
dcterms.dateAccepted2017-10-09
dc.identifier.eissn1468-330X
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1136/jnnp-2017-316415
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-02
rioxxterms.typeJournal Article/Review


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record


All items in PEARL are protected by copyright law.
Author manuscripts deposited to comply with open access mandates are made available in accordance with publisher policies. Please cite only the published version using the details provided on the item record or document. In the absence of an open licence (e.g. Creative Commons), permissions for further reuse of content should be sought from the publisher or author.
Theme by 
Atmire NV