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dc.contributor.authorBarranger, A
dc.contributor.authorRance, GA
dc.contributor.authorAminot, Y
dc.contributor.authorDallas, LJ
dc.contributor.authorSforzini, S
dc.contributor.authorWeston, NJ
dc.contributor.authorLodge, RW
dc.contributor.authorBanni, M
dc.contributor.authorArlt, VM
dc.contributor.authorMoore, MN
dc.contributor.authorReadman, JW
dc.contributor.authorViarengo, A
dc.contributor.authorKhlobystov, AN
dc.contributor.authorJha, Awadhesh
dc.date.accessioned2019-09-03T13:00:54Z
dc.date.available2019-09-03T13:00:54Z
dc.date.issued2019-11-26
dc.identifier.issn1743-5390
dc.identifier.issn1743-5404
dc.identifier.urihttp://hdl.handle.net/10026.1/14867
dc.description.abstract

The interactions between carbon-based engineered nanoparticles (ENPs) and organic pollutants might enhance the uptake of contaminants into biota. The present integrated study aimed to assess this potential 'Trojan Horse', probing the interactive effects of purpose-made multi-walled carbon nanotubes (MWCNTs), a representative ENP, and benzo[a]pyrene (BaP), a ubiquitous polycyclic aromatic hydrocarbon (PAH) pollutant, on the marine mussel Mytilus galloprovincialis. Mussels were exposed to MWCNTs and BaP either alone or in various combinations. The co-exposure of BaP with MWCNTs revealed that the presence of MWCNTs enhanced the aqueous concentrations of BaP, thereby reducing the uptake of this pollutant by mussels as evidenced by lowering BaP concentrations in the tissues. Determination of DNA damage (comet assay) showed a concentration-dependent response for BaP alone which was absent when MWCNTs were present. Global gene expression using microarray analyses indicated that BaP and MWCNTs, in combination, differentially activated those genes which are involved in DNA metabolism compared to the exposures of BaP or MWCNTs alone, and the gene expression response was tissue-specific. Mechanisms to explain these results are discussed and relate primarily to the adsorption of BaP on MWCNTs, mediated potentially by van der Waals interactions. The use of a novel approach based on gold-labeled MWCNTs to track their uptake in tissues improved the traceability of nanotubes in biological samples. Overall, our results did not indicate the 'Trojan Horse' effects following co-exposure to the contaminants and clearly showed that the adsorption of BaP to MWCNTs modified the uptake of the pollutant in marine mussels.

dc.format.extent1324-1343
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoen
dc.publisherInforma UK Limited
dc.subjectMytilus galloprovincialis
dc.subjectbenzo[a]pyrene
dc.subjectmulti-walled carbon nanotubes
dc.subjectvan der Waals interactions
dc.subjectadsorption
dc.titleAn integrated approach to determine interactive genotoxic and global gene expression effects of multiwalled carbon nanotubes (MWCNTs) and benzo[a]pyrene (BaP) on marine mussels: evidence of reverse ‘Trojan Horse’ effects
dc.typejournal-article
dc.typeJournal Article
dc.typeResearch Support, Non-U.S. Gov't
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000484636700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue10
plymouth.volume13
plymouth.publication-statusPublished
plymouth.journalNanotoxicology
dc.identifier.doi10.1080/17435390.2019.1654003
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Admin Group - REF
plymouth.organisational-group/Plymouth/Admin Group - REF/REF Admin Group - FoSE
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Biological and Marine Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA06 Agriculture, Veterinary and Food Science
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA06 Agriculture, Veterinary and Food Science/UoA06 Agriculture, Veterinary and Food Science MANUAL
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Marine Institute
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
plymouth.organisational-group/Plymouth/Users by role/Researchers in ResearchFish submission
dc.publisher.placeEngland
dcterms.dateAccepted2019-08-05
dc.rights.embargodate2020-8-28
dc.identifier.eissn1743-5404
dc.rights.embargoperiodNot known
rioxxterms.versionAccepted Manuscript
rioxxterms.versionofrecord10.1080/17435390.2019.1654003
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
plymouth.funderElucidating the potential interaction of manufactured nanoparticles with polycyclic aromatic hydrocarbons: An integrated toxicogenomics approach::NERC


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