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dc.contributor.authorDenes, BJ
dc.contributor.authorBolton, C
dc.contributor.authorIllsley, C
dc.contributor.authorKok, W
dc.contributor.authorWalker, J
dc.contributor.authorPoetsch, A
dc.contributor.authorTredwin, Christopher
dc.contributor.authorKiliaridis, S
dc.contributor.authorHu, Bing
dc.date.accessioned2019-08-29T09:34:09Z
dc.date.issued2019-08-28
dc.identifier.issn0022-0345
dc.identifier.issn1544-0591
dc.identifier.other0
dc.identifier.urihttp://hdl.handle.net/10026.1/14822
dc.descriptionNo embargo required.
dc.description.abstract

<jats:p>Tooth eruption is a continuous biological process with dynamic changes at cellular and tissue levels, particularly within the periodontal ligament (PDL). Occlusion completion is a significant physiological landmark of dentition establishment. However, the importance of the involvement of molecular networks engaging in occlusion establishment on the final PDL maturation is still largely unknown. In this study, using rat and mouse molar teeth and a human PDL cell line for RNAseq and proteomic analysis, we systematically screened the key molecular links in regulating PDL maturation before and after occlusion establishment. We discovered Notch, a key molecular pathway in regulating stem cell fate and differentiation, is a major player in the event. Intercepting the Notch pathway by deleting its key canonical transcriptional factor, RBP-Jkappa, using a conditional knockout strategy in the mice delayed PDL maturation. We also identified that Lamin A, a cell nuclear lamina member, is a unique marker of PDL maturation, and its expression is under the control of Notch signaling. Our study therefore provides a deep insight of how PDL maturation is regulated at the molecular level, and we expect the outcomes to be applied for a better understanding of the molecular regulation networks in physiological conditions such as tooth eruption and movement and also for periodontal diseases.</jats:p>

dc.format.extent1357-1366
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoen
dc.publisherSAGE Publications
dc.subjecttooth
dc.subjectdentition
dc.subjectodontogenesis
dc.subjectstem cells
dc.subjectcytoskeleton
dc.subjectextracellular matrix
dc.titleNotch Coordinates Periodontal Ligament Maturation through Regulating Lamin A
dc.typejournal-article
dc.typeJournal Article
dc.typeResearch Support, Non-U.S. Gov't
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000484452000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue12
plymouth.volume98
plymouth.publication-statusPublished
plymouth.journalJournal of Dental Research
dc.identifier.doi10.1177/0022034519871448
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Dental School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
plymouth.organisational-group/Plymouth/Users by role/Researchers in ResearchFish submission
dc.publisher.placeUnited States
dcterms.dateAccepted2019-08-02
dc.rights.embargodate2019-11-26
dc.identifier.eissn1544-0591
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1177/0022034519871448
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-08-28
rioxxterms.typeJournal Article/Review
plymouth.funderRole of the FoxN1 gene as a central regulator of epidermal planar cell polarity signaling expression and function::BBSRC


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