Notch Coordinates Periodontal Ligament Maturation through Regulating Lamin A
dc.contributor.author | Denes, BJ | |
dc.contributor.author | Bolton, C | |
dc.contributor.author | Illsley, C | |
dc.contributor.author | Kok, W | |
dc.contributor.author | Walker, J | |
dc.contributor.author | Poetsch, A | |
dc.contributor.author | Tredwin, Christopher | |
dc.contributor.author | Kiliaridis, S | |
dc.contributor.author | Hu, Bing | |
dc.date.accessioned | 2019-08-29T09:34:09Z | |
dc.date.issued | 2019-08-28 | |
dc.identifier.issn | 0022-0345 | |
dc.identifier.issn | 1544-0591 | |
dc.identifier.other | 0 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/14822 | |
dc.description | No embargo required. | |
dc.description.abstract |
<jats:p>Tooth eruption is a continuous biological process with dynamic changes at cellular and tissue levels, particularly within the periodontal ligament (PDL). Occlusion completion is a significant physiological landmark of dentition establishment. However, the importance of the involvement of molecular networks engaging in occlusion establishment on the final PDL maturation is still largely unknown. In this study, using rat and mouse molar teeth and a human PDL cell line for RNAseq and proteomic analysis, we systematically screened the key molecular links in regulating PDL maturation before and after occlusion establishment. We discovered Notch, a key molecular pathway in regulating stem cell fate and differentiation, is a major player in the event. Intercepting the Notch pathway by deleting its key canonical transcriptional factor, RBP-Jkappa, using a conditional knockout strategy in the mice delayed PDL maturation. We also identified that Lamin A, a cell nuclear lamina member, is a unique marker of PDL maturation, and its expression is under the control of Notch signaling. Our study therefore provides a deep insight of how PDL maturation is regulated at the molecular level, and we expect the outcomes to be applied for a better understanding of the molecular regulation networks in physiological conditions such as tooth eruption and movement and also for periodontal diseases.</jats:p> | |
dc.format.extent | 1357-1366 | |
dc.format.medium | Print-Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | SAGE Publications | |
dc.subject | tooth | |
dc.subject | dentition | |
dc.subject | odontogenesis | |
dc.subject | stem cells | |
dc.subject | cytoskeleton | |
dc.subject | extracellular matrix | |
dc.title | Notch Coordinates Periodontal Ligament Maturation through Regulating Lamin A | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Research Support, Non-U.S. Gov't | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000484452000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 12 | |
plymouth.volume | 98 | |
plymouth.publication-status | Published | |
plymouth.journal | Journal of Dental Research | |
dc.identifier.doi | 10.1177/0022034519871448 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Dental School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2019-08-02 | |
dc.rights.embargodate | 2019-11-26 | |
dc.identifier.eissn | 1544-0591 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1177/0022034519871448 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2019-08-28 | |
rioxxterms.type | Journal Article/Review | |
plymouth.funder | Role of the FoxN1 gene as a central regulator of epidermal planar cell polarity signaling expression and function::BBSRC |