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dc.contributor.authorWalker, JVen
dc.contributor.authorZhuang, Hen
dc.contributor.authorSinger, Den
dc.contributor.authorIllsley, CSen
dc.contributor.authorKok, WLen
dc.contributor.authorSivaraj, KKen
dc.contributor.authorGao, Yen
dc.contributor.authorBolton, Cen
dc.contributor.authorLiu, Yen
dc.contributor.authorZhao, Men
dc.contributor.authorGrayson, PRCen
dc.contributor.authorWang, Sen
dc.contributor.authorKarbanová, Jen
dc.contributor.authorLee, Ten
dc.contributor.authorArdu, Sen
dc.contributor.authorLai, Qen
dc.contributor.authorLiu, Jen
dc.contributor.authorKassem, Men
dc.contributor.authorChen, Sen
dc.contributor.authorYang, Ken
dc.contributor.authorBai, Yen
dc.contributor.authorTredwin, Cen
dc.contributor.authorZambon, ACen
dc.contributor.authorCorbeil, Den
dc.contributor.authorAdams, Ren
dc.contributor.authorAbdallah, BMen
dc.contributor.authorHu, Ben

Stem cells (SCs) receive inductive cues from the surrounding microenvironment and cells. Limited molecular evidence has connected tissue-specific mesenchymal stem cells (MSCs) with mesenchymal transit amplifying cells (MTACs). Using mouse incisor as the model, we discover a population of MSCs neibouring to the MTACs and epithelial SCs. With Notch signaling as the key regulator, we disclose molecular proof and lineage tracing evidence showing the distinct MSCs contribute to incisor MTACs and the other mesenchymal cell lineages. MTACs can feedback and regulate the homeostasis and activation of CL-MSCs through Delta-like 1 homolog (Dlk1), which balances MSCs-MTACs number and the lineage differentiation. Dlk1's function on SCs priming and self-renewal depends on its biological forms and its gene expression is under dynamic epigenetic control. Our findings can be validated in clinical samples and applied to accelerate tooth wound healing, providing an intriguing insight of how to direct SCs towards tissue regeneration.

dc.format.extent3596 - ?en
dc.titleTransit amplifying cells coordinate mouse incisor mesenchymal stem cell activation.en
dc.typeJournal Article
plymouth.publication-statusPublished onlineen
plymouth.journalNat Communen
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Health: Medicine, Dentistry and Human Sciences
plymouth.organisational-group/Plymouth/Faculty of Health: Medicine, Dentistry and Human Sciences/Peninsula Dental School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
dc.rights.embargoperiodNot knownen
rioxxterms.typeJournal Article/Reviewen

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