Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation
dc.contributor.author | Walker, JV | |
dc.contributor.author | Zhuang, H | |
dc.contributor.author | Singer, Donald | |
dc.contributor.author | Illsley, CS | |
dc.contributor.author | Kok, WL | |
dc.contributor.author | Sivaraj, KK | |
dc.contributor.author | Gao, Y | |
dc.contributor.author | Bolton, C | |
dc.contributor.author | Liu, Y | |
dc.contributor.author | Zhao, M | |
dc.contributor.author | Grayson, PRC | |
dc.contributor.author | Wang, S | |
dc.contributor.author | Karbanová, J | |
dc.contributor.author | Lee, T | |
dc.contributor.author | Ardu, S | |
dc.contributor.author | Lai, Q | |
dc.contributor.author | Liu, J | |
dc.contributor.author | Kassem, M | |
dc.contributor.author | Chen, S | |
dc.contributor.author | Yang, K | |
dc.contributor.author | Bai, Y | |
dc.contributor.author | Tredwin, Christopher | |
dc.contributor.author | Zambon, AC | |
dc.contributor.author | Corbeil, D | |
dc.contributor.author | Adams, R | |
dc.contributor.author | Abdallah, BM | |
dc.contributor.author | Hu, Bing | |
dc.date.accessioned | 2019-08-09T11:11:07Z | |
dc.date.available | 2019-08-09T11:11:07Z | |
dc.date.issued | 2019-08-09 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.other | 3596 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/14782 | |
dc.description.abstract |
<jats:title>Abstract</jats:title><jats:p>Stem cells (SCs) receive inductive cues from the surrounding microenvironment and cells. Limited molecular evidence has connected tissue-specific mesenchymal stem cells (MSCs) with mesenchymal transit amplifying cells (MTACs). Using mouse incisor as the model, we discover a population of MSCs neibouring to the MTACs and epithelial SCs. With<jats:italic>Notch</jats:italic>signaling as the key regulator, we disclose molecular proof and lineage tracing evidence showing the distinct MSCs contribute to incisor MTACs and the other mesenchymal cell lineages. MTACs can feedback and regulate the homeostasis and activation of CL-MSCs through Delta-like 1 homolog (Dlk1), which balances MSCs-MTACs number and the lineage differentiation.<jats:italic>Dlk1</jats:italic>’s function on SCs priming and self-renewal depends on its biological forms and its gene expression is under dynamic epigenetic control. Our findings can be validated in clinical samples and applied to accelerate tooth wound healing, providing an intriguing insight of how to direct SCs towards tissue regeneration.</jats:p> | |
dc.format.extent | 0-0 | |
dc.format.medium | Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Nature Research (part of Springer Nature) | |
dc.subject | Animals | |
dc.subject | Calcium-Binding Proteins | |
dc.subject | Cell Differentiation | |
dc.subject | Cell Lineage | |
dc.subject | Dentin | |
dc.subject | Epigenomics | |
dc.subject | Female | |
dc.subject | Gene Expression | |
dc.subject | Homeostasis | |
dc.subject | Humans | |
dc.subject | Incisor | |
dc.subject | Mesenchymal Stem Cell Transplantation | |
dc.subject | Mesenchymal Stem Cells | |
dc.subject | Mice | |
dc.subject | Mice, Knockout | |
dc.subject | Models, Animal | |
dc.subject | Molar, Third | |
dc.subject | Rats | |
dc.subject | Rats, Wistar | |
dc.subject | Signal Transduction | |
dc.subject | Stem Cell Niche | |
dc.subject | Wound Healing | |
dc.title | Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Research Support, N.I.H., Extramural | |
dc.type | Research Support, Non-U.S. Gov't | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000480234500010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 1 | |
plymouth.volume | 10 | |
plymouth.publication-status | Published online | |
plymouth.journal | Nature Communications | |
dc.identifier.doi | 10.1038/s41467-019-11611-0 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Dental School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | England | |
dcterms.dateAccepted | 2019-07-26 | |
dc.rights.embargodate | 2019-8-28 | |
dc.identifier.eissn | 2041-1723 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.version | Version of Record | |
rioxxterms.versionofrecord | 10.1038/s41467-019-11611-0 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2019-08-09 | |
rioxxterms.type | Journal Article/Review | |
plymouth.funder | Role of the FoxN1 gene as a central regulator of epidermal planar cell polarity signaling expression and function::BBSRC |