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dc.contributor.authorWalker, JV
dc.contributor.authorZhuang, H
dc.contributor.authorSinger, D
dc.contributor.authorIllsley, CS
dc.contributor.authorKok, WL
dc.contributor.authorSivaraj, KK
dc.contributor.authorGao, Y
dc.contributor.authorBolton, C
dc.contributor.authorLiu, Y
dc.contributor.authorZhao, M
dc.contributor.authorGrayson, PRC
dc.contributor.authorWang, S
dc.contributor.authorKarbanová, J
dc.contributor.authorLee, T
dc.contributor.authorArdu, S
dc.contributor.authorLai, Q
dc.contributor.authorLiu, J
dc.contributor.authorKassem, M
dc.contributor.authorChen, S
dc.contributor.authorYang, K
dc.contributor.authorBai, Y
dc.contributor.authorTredwin, C
dc.contributor.authorZambon, AC
dc.contributor.authorCorbeil, D
dc.contributor.authorAdams, R
dc.contributor.authorAbdallah, BM
dc.contributor.authorHu, B
dc.date.accessioned2019-08-09T11:11:07Z
dc.date.available2019-08-09T11:11:07Z
dc.date.issued2019-08-09
dc.identifier.issn2041-1723
dc.identifier.issn2041-1723
dc.identifier.other3596
dc.identifier.urihttp://hdl.handle.net/10026.1/14782
dc.description.abstract

<jats:title>Abstract</jats:title><jats:p>Stem cells (SCs) receive inductive cues from the surrounding microenvironment and cells. Limited molecular evidence has connected tissue-specific mesenchymal stem cells (MSCs) with mesenchymal transit amplifying cells (MTACs). Using mouse incisor as the model, we discover a population of MSCs neibouring to the MTACs and epithelial SCs. With<jats:italic>Notch</jats:italic>signaling as the key regulator, we disclose molecular proof and lineage tracing evidence showing the distinct MSCs contribute to incisor MTACs and the other mesenchymal cell lineages. MTACs can feedback and regulate the homeostasis and activation of CL-MSCs through Delta-like 1 homolog (Dlk1), which balances MSCs-MTACs number and the lineage differentiation.<jats:italic>Dlk1</jats:italic>’s function on SCs priming and self-renewal depends on its biological forms and its gene expression is under dynamic epigenetic control. Our findings can be validated in clinical samples and applied to accelerate tooth wound healing, providing an intriguing insight of how to direct SCs towards tissue regeneration.</jats:p>

dc.format.extent0-0
dc.format.mediumElectronic
dc.languageen
dc.language.isoen
dc.publisherNature Research (part of Springer Nature)
dc.subjectAnimals
dc.subjectCalcium-Binding Proteins
dc.subjectCell Differentiation
dc.subjectCell Lineage
dc.subjectDentin
dc.subjectEpigenomics
dc.subjectFemale
dc.subjectGene Expression
dc.subjectHomeostasis
dc.subjectHumans
dc.subjectIncisor
dc.subjectMesenchymal Stem Cell Transplantation
dc.subjectMesenchymal Stem Cells
dc.subjectMice
dc.subjectMice, Knockout
dc.subjectModels, Animal
dc.subjectMolar, Third
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSignal Transduction
dc.subjectStem Cell Niche
dc.subjectWound Healing
dc.titleTransit amplifying cells coordinate mouse incisor mesenchymal stem cell activation
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/31399601
plymouth.issue1
plymouth.volume10
plymouth.publisher-urlhttp://dx.doi.org/10.1038/s41467-019-11611-0
plymouth.publication-statusPublished online
plymouth.journalNature Communications
dc.identifier.doi10.1038/s41467-019-11611-0
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Dental School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
plymouth.organisational-group/Plymouth/Users by role/Researchers in ResearchFish submission
dc.publisher.placeEngland
dcterms.dateAccepted2019-07-26
dc.rights.embargodate2019-8-28
dc.identifier.eissn2041-1723
dc.rights.embargoperiodNot known
rioxxterms.versionVersion of Record
rioxxterms.versionofrecord10.1038/s41467-019-11611-0
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-08-09
rioxxterms.typeJournal Article/Review
plymouth.funderRole of the FoxN1 gene as a central regulator of epidermal planar cell polarity signaling expression and function::BBSRC


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