Browsing School of Biomedical Sciences by Title

Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo.

Fejer, G; Drechsel, L; Liese, J; Schleicher, U; Ruzsics, Z; Imelli, N; Greber, UF; Keck, S; Hildenbrand, B; Krug, A; Bogdan, C; Freudenberg, MA (United States, 2008-11)

The early systemic production of interferon (IFN)-alphabeta is an essential component of the antiviral host defense mechanisms, but is also thought to contribute to the toxic side effects accompanying gene therapy with ...

Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages.

Maler, MD; Nielsen, PJ; Stichling, N; Cohen, I; Ruzsics, Z; Wood, C; Engelhard, P; Suomalainen, M; Gyory, I; Huber, M; Müller-Quernheim, J; Schamel, WWA; Gordon, S; Jakob, T; Martin, SF; Jahnen-Dechent, W; Greber, UF; Freudenberg, MA; Fejer, G (United States, 2017-08-01)

The scavenger receptor MARCO is expressed in several subsets of naive tissue-resident macrophages and has been shown to participate in the recognition of various bacterial pathogens. However, the role of MARCO in antiviral ...

Kinetic Measurements of Di- and Tripeptide and Peptidomimetic Drug Transport in Different Kidney Regions Using the Fluorescent Membrane Potential-Sensitive Dye, DiS-C3-(3).

Alghamdi, OA; King, N; Jones, GL; Moens, PDJ (Springer Verlag, 2017-12)

Tri- and dipeptides are transported in the kidney by PEPT1 and PEPT2 isoforms. The aim of this study was to investigate differences in transport kinetics between renal brush border (BBMV) and outer medulla (OMMV) membrane ...

Lactobacillus casei strain Shirota selectively modulates macrophage subset cytokine production

Habil, N; Beal, J; Foey, AD (2012-12-01)

Probiotics confer health benefits through many mechanisms including modulation of the gut immune system, dut macrophages regulate immune homeostasis, mounting tolerogenic responses to food and commensal bacteria or immune ...

LCCL protein complex formation in Plasmodium is critically dependent on LAP1.

Tremp, AZ; Sharma, V; Carter, V; Lasonder, E; Dessens, JT (2017-04-13)

Successful sporogony of Plasmodium berghei in vector mosquitoes requires expression of a family of six modular proteins named LCCL lectin domain adhesive-like proteins (LAPs). The LAPs share a subcellular localization in ...

Letter to the Editor

Del Águila-Carrasco, AJ; Marín-Franch, I (Elsevier, 2018-03-22)

Lineage-Specific Methyltransferases Define the Methylome of the Globally Disseminated Escherichia coli ST131 Clone.

Forde, BM; Phan, M-D; Gawthorne, JA; Ashcroft, MM; Stanton-Cook, M; Sarkar, S; Peters, KM; Chan, K-G; Chong, TM; Yin, W-F; Upton, M; Schembri, MA; Beatson, SA (United States, 2015-11-17)

UNLABELLED: Escherichia coli sequence type 131 (ST131) is a clone of uropathogenic E. coli that has emerged rapidly and disseminated globally in both clinical and community settings. Members of the ST131 lineage from ...

Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis.

Recknagel, P; Gonnert, FA; Westermann, M; Lambeck, S; Lupp, A; Rudiger, A; Dyson, A; Carré, JE; Kortgen, A; Krafft, C; Popp, J; Sponholz, C; Fuhrmann, V; Hilger, I; Claus, RA; Riedemann, NC; Wetzker, R; Singer, M; Trauner, M; Bauer, M (United States, 2012)

BACKGROUND: Hepatic dysfunction and jaundice are traditionally viewed as late features of sepsis and portend poor outcomes. We hypothesized that changes in liver function occur early in the onset of sepsis, yet pass ...

LonB Protease Is a Novel Regulator of Carotenogenesis Controlling Degradation of Phytoene Synthase in Haloferax volcanii

Cerletti, M; Paggi, R; Troetschel, C; Ferrari, MC; Guevara, CR; Albaum, S; Poetsch, A; De Castro, R (American Chemical Society, 2018-03-02)

Long-term outcomes of on vs. off pump coronary artery bypass grafting

Smart, N; Dieberg, G; King, N (Elsevier, 2018-03-06)

Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor.

Stichling, N; Suomalainen, M; Flatt, JW; Schmid, M; Pacesa, M; Hemmi, S; Jungraithmayr, W; Maler, MD; Freudenberg, MA; Plückthun, A; May, T; Köster, M; Fejer, G; Greber, UF (United States, 2018-03)

Macrophages are a diverse group of phagocytic cells acting in host protection against stress, injury, and pathogens. Here, we show that the scavenger receptor SR-A6 is an entry receptor for human adenoviruses in murine ...

Macrophage subset sensitivity to endotoxin tolerisation by Porphyromonas gingivalis.

Foey, AD; Crean, S (United States, 2013)

Macrophages (MΦs) determine oral mucosal responses; mediating tolerance to commensal microbes and food whilst maintaining the capacity to activate immune defences to pathogens. MΦ responses are determined by both ...

Macrophage subsets exhibit distinct E. coli-LPS tolerisable cytokines associated with the negative regulators, IRAK-M and Tollip

Al-Shaghdali, K; Durante, B; Hayward, C; Beal, J; Foey, A (Public Library of Science, 2019-05-23)

Mid-pregnancy changes in maternal upper body subcutaneous fat assessed using skinfold measurements and oral glucose tolerance test results amongst women with obesity in the UK

Redfern, K; Pinkney, J; Rees, G (Karger Publishers Open Access, 2019-04-17)