Cytokine regulation in RA synovial tissue: role of T cell/macrophage contact-dependent interactions
dc.contributor.author | Brennan, F | |
dc.contributor.author | Foey, Andrew | |
dc.date.accessioned | 2019-07-10T12:41:22Z | |
dc.date.available | 2019-07-10T12:41:22Z | |
dc.date.issued | 2002 | |
dc.identifier.issn | 1465-9905 | |
dc.identifier.issn | 1478-6362 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/14624 | |
dc.description.abstract |
Several groups have documented the expression of cytokines in rheumatoid arthritis synovial tissue over the past 15 years or so. These studies have indicated that most cytokines examined are expressed at the mRNA levels at least, and many other cytokines are found in abundance as proteins. Our attention has recently focused on the mechanisms that induce and regulate tumour necrosis factor and IL-10. Other workers and ourselves have found that cell-cell contact is an important signal for the induction of cytokines, and our work has demonstrated that tumour necrosis factor and IL-10 production in rheumatoid arthritis synovial joint cells cultures is dependent on T cell/macrophage interaction. In this chapter, we review recent advances in this area and also highlight areas where new therapeutic intervention opportunities arise. | |
dc.format.extent | S177-S177 | |
dc.format.medium | Print-Electronic | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.subject | cognate | |
dc.subject | differentiation | |
dc.subject | macrophage | |
dc.subject | signalling | |
dc.subject | T cells | |
dc.title | Cytokine regulation in RA synovial tissue: role of T cell/macrophage contact-dependent interactions | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Research Support, Non-U.S. Gov't | |
dc.type | Review | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209967200020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | Suppl 3 | |
plymouth.volume | 4 | |
plymouth.publication-status | Published | |
plymouth.journal | Arthritis Research | |
dc.identifier.doi | 10.1186/ar556 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/School of Biomedical Sciences | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | England | |
dcterms.dateAccepted | 2002-03-05 | |
dc.identifier.eissn | 1478-6362 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1186/ar556 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2002 | |
rioxxterms.type | Journal Article/Review |