Show simple item record

dc.contributor.authorDavison, G
dc.contributor.authorJones, AW
dc.contributor.authorMarchbank, Tania
dc.contributor.authorPlayford, Raymond
dc.date.accessioned2019-06-24T20:11:19Z
dc.date.issued2019-05-23
dc.identifier.issn1436-6207
dc.identifier.issn1436-6215
dc.identifier.urihttp://hdl.handle.net/10026.1/14421
dc.description.abstract

PURPOSE: Bovine colostrum is available in health food shops and as a sports food supplement and is rich in antibodies and growth factors including IGF-1. World Anti-Doping Agency advises athletes against taking colostrum for fear of causing increased plasma IGF-1. There are also concerns that colostrum may theoretically stimulate malignancy in organs which express IGF-1 receptors. We, therefore, determined changes in plasma IGF-1 levels in subjects taking colostrum or placebo for 1 day, 4 weeks, and 12 weeks. METHODS: Plasma IGF1 levels were determined in healthy males (n = 16) who ingested 40 g bovine colostrum or placebo along with undertaking moderate exercise for total period of 4.5 h. Two further studies followed changes in IGF1 using double-blind, parallel group, placebo-controlled, randomized trials of colostrum or placebo (N = 10 per arm, 20 g/day for 4 weeks and N = 25 colostrum, N = 29 placebo arm 20 g/day for 12 weeks). RESULTS: Baseline IGF1 levels 130 ± 36 ng/ml. 4.5 h protocol showed no effect of colostrum on plasma IGF1 (ANOVA, treatment group: p = 0.400, group × time: p = 0.498, time p = 0.602). Similarly, no effect of colostrum ingestion was seen following 4 week (ANOVA, group: p = 0.584, group × time interaction: p = 0.083, time p = 0.243) or 12 week (ANOVA, group: p = 0.400, group × time interaction: p = 0.498, time p = 0.602) protocol. CONCLUSIONS: Ingestion of standard recommended doses of colostrum does not increase IGF-1 levels in healthy adults, providing additional support for the safety profile of colostrum ingestion.

dc.format.extent1473-1479
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoen
dc.publisherSpringer (part of Springer Nature)
dc.subjectNutraceutical
dc.subjectSports nutrition
dc.subjectFood supplement
dc.subjectProstate cancer
dc.titleOral bovine colostrum supplementation does not increase circulating insulin-like growth factor-1 concentration in healthy adults: results from short- and long-term administration studies
dc.typejournal-article
dc.typeJournal Article
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000533461100017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue4
plymouth.volume59
plymouth.publication-statusPublished
plymouth.journalEuropean Journal of Nutrition
dc.identifier.doi10.1007/s00394-019-02004-6
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
dc.publisher.placeGermany
dcterms.dateAccepted2019-05-16
dc.rights.embargodate2019-7-5
dc.identifier.eissn1436-6215
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1007/s00394-019-02004-6
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-05-23
rioxxterms.typeJournal Article/Review


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record


All items in PEARL are protected by copyright law.
Author manuscripts deposited to comply with open access mandates are made available in accordance with publisher policies. Please cite only the published version using the details provided on the item record or document. In the absence of an open licence (e.g. Creative Commons), permissions for further reuse of content should be sought from the publisher or author.
Theme by 
Atmire NV