Discovery of Volatile Biomarkers of Parkinson’s Disease from Sebum
dc.contributor.author | Trivedi, DK | |
dc.contributor.author | Sinclair, E | |
dc.contributor.author | Xu, Y | |
dc.contributor.author | Sarkar, D | |
dc.contributor.author | Walton-Doyle, C | |
dc.contributor.author | Liscio, C | |
dc.contributor.author | Banks, P | |
dc.contributor.author | Milne, J | |
dc.contributor.author | Silverdale, M | |
dc.contributor.author | Kunath, T | |
dc.contributor.author | Goodacre, R | |
dc.contributor.author | Barran, P | |
dc.date.accessioned | 2019-06-13T12:00:51Z | |
dc.date.available | 2019-06-13T12:00:51Z | |
dc.date.issued | 2019-04-24 | |
dc.identifier.issn | 2374-7943 | |
dc.identifier.issn | 2374-7951 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/14314 | |
dc.description.abstract |
Parkinson's disease (PD) is a progressive, neurodegenerative disease that presents with significant motor symptoms, for which there is no diagnostic chemical test. We have serendipitously identified a hyperosmic individual, a "Super Smeller" who can detect PD by odor alone, and our early pilot studies have indicated that the odor was present in the sebum from the skin of PD subjects. Here, we have employed an unbiased approach to investigate the volatile metabolites of sebum samples obtained noninvasively from the upper back of 64 participants in total (21 controls and 43 PD subjects). Our results, validated by an independent cohort (n=31), identified a distinct volatiles-associated signature of PD, including altered levels of perillic aldehyde and eicosane, the smell of which was then described as being highly similar to the scent of PD by our "Super Smeller". | |
dc.format.extent | 599-606 | |
dc.format.medium | Print-Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | American Chemical Society | |
dc.subject | Brain Disorders | |
dc.subject | Parkinson's Disease | |
dc.subject | Neurodegenerative | |
dc.subject | Neurosciences | |
dc.subject | Clinical Research | |
dc.subject | Aging | |
dc.subject | 2.1 Biological and endogenous factors | |
dc.subject | 4.1 Discovery and preclinical testing of markers and technologies | |
dc.subject | Neurological | |
dc.title | Discovery of Volatile Biomarkers of Parkinson’s Disease from Sebum | |
dc.type | journal-article | |
dc.type | Journal Article | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000465530600007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 4 | |
plymouth.volume | 5 | |
plymouth.publication-status | Published | |
plymouth.journal | ACS Central Science | |
dc.identifier.doi | 10.1021/acscentsci.8b00879 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/FoH - Applied Parkinson's Research | |
plymouth.organisational-group | /Plymouth/Research Groups/FoH - Community and Primary Care | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CCT&PS | |
plymouth.organisational-group | /Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR) | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2019-02-22 | |
dc.rights.embargodate | 2019-12-7 | |
dc.identifier.eissn | 2374-7951 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1021/acscentsci.8b00879 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2019-04-24 | |
rioxxterms.type | Journal Article/Review |