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dc.contributor.authorTrivedi, DK
dc.contributor.authorSinclair, E
dc.contributor.authorXu, Y
dc.contributor.authorSarkar, D
dc.contributor.authorWalton-Doyle, C
dc.contributor.authorLiscio, C
dc.contributor.authorBanks, P
dc.contributor.authorMilne, J
dc.contributor.authorSilverdale, M
dc.contributor.authorKunath, T
dc.contributor.authorGoodacre, R
dc.contributor.authorBarran, P
dc.date.accessioned2019-06-13T12:00:51Z
dc.date.available2019-06-13T12:00:51Z
dc.date.issued2019-04-24
dc.identifier.issn2374-7943
dc.identifier.issn2374-7951
dc.identifier.urihttp://hdl.handle.net/10026.1/14314
dc.description.abstract

Parkinson's disease (PD) is a progressive, neurodegenerative disease that presents with significant motor symptoms, for which there is no diagnostic chemical test. We have serendipitously identified a hyperosmic individual, a "Super Smeller" who can detect PD by odor alone, and our early pilot studies have indicated that the odor was present in the sebum from the skin of PD subjects. Here, we have employed an unbiased approach to investigate the volatile metabolites of sebum samples obtained noninvasively from the upper back of 64 participants in total (21 controls and 43 PD subjects). Our results, validated by an independent cohort (n=31), identified a distinct volatiles-associated signature of PD, including altered levels of perillic aldehyde and eicosane, the smell of which was then described as being highly similar to the scent of PD by our "Super Smeller".

dc.format.extent599-606
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subjectBrain Disorders
dc.subjectParkinson's Disease
dc.subjectNeurodegenerative
dc.subjectNeurosciences
dc.subjectClinical Research
dc.subjectAging
dc.subject2.1 Biological and endogenous factors
dc.subject4.1 Discovery and preclinical testing of markers and technologies
dc.subjectNeurological
dc.titleDiscovery of Volatile Biomarkers of Parkinson’s Disease from Sebum
dc.typejournal-article
dc.typeJournal Article
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000465530600007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue4
plymouth.volume5
plymouth.publication-statusPublished
plymouth.journalACS Central Science
dc.identifier.doi10.1021/acscentsci.8b00879
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/FoH - Applied Parkinson's Research
plymouth.organisational-group/Plymouth/Research Groups/FoH - Community and Primary Care
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CCT&PS
plymouth.organisational-group/Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR)
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeUnited States
dcterms.dateAccepted2019-02-22
dc.rights.embargodate2019-12-7
dc.identifier.eissn2374-7951
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1021/acscentsci.8b00879
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-04-24
rioxxterms.typeJournal Article/Review


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