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dc.contributor.authorPuleston, D.
dc.date.accessioned2019-05-13T13:36:33Z
dc.date.available2019-05-13T13:36:33Z
dc.date.issued2009
dc.identifier.citation

Puleston, D. (2009) 'The role of reactive oxygen species in oxidative-induced neoplastic transformation', The Plymouth Student Scientist, p. 279-288.

en_US
dc.identifier.issn1754-2383
dc.identifier.urihttp://hdl.handle.net/10026.1/13881
dc.description.abstract

The generation of reactive oxygen species (ROS) is a normal occurrence in the life of a cell. ROS are derived from both exogenous and endogenous sources and take part in a plethora of normal physiological mechanisms from host immunity to cell cycle regulation. However, ROS also exhibit a deleterious, disruptive character that means they must now be taken seriously as a genuine carcinogenic agent able to alter a variety of pathways leading to the initiation of cancer. The two-sidedness of ROS means that the relationship between ROS and the onset and progression of cancer is hard to determine. ROS and reactive nitrogen species (RNS) are able to initiate cancer through the damage of DNA leading to the genetic instability that drives the early stages of cancer. Simultaneously, they can activate a number of signalling cascades and transcription factors that facilitate uncontrolled cell growth. The production of ROS in neoplastic cells can lead to the production of new blood vessels that provide the machinery for subsequent metastasis and tumour invasion. It is important that the role of ROS in these pathways are fully elucidated in order to provide potential therapies measures.

en_US
dc.language.isoenen_US
dc.publisherUniversity of Plymouth
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectDNAen_US
dc.subjectreactive oxygen speciesen_US
dc.subjectROSen_US
dc.subjectcarcinogenicen_US
dc.subjectNeoplastic Transformationen_US
dc.subjectcellen_US
dc.subjectcell cycle regulationen_US
dc.titleThe role of reactive oxygen species in oxidative-induced neoplastic transformationen_US
dc.typeArticle
plymouth.issue2
plymouth.volume2
plymouth.journalThe Plymouth Student Scientist


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Attribution 3.0 United States
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