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dc.contributor.authorWitt, SH
dc.contributor.authorStreit, F
dc.contributor.authorJungkunz, M
dc.contributor.authorFrank, J
dc.contributor.authorAwasthi, S
dc.contributor.authorReinbold, CS
dc.contributor.authorTreutlein, J
dc.contributor.authorDegenhardt, F
dc.contributor.authorForstner, AJ
dc.contributor.authorHeilmann-Heimbach, S
dc.contributor.authorDietl, L
dc.contributor.authorSchwarze, CE
dc.contributor.authorSchendel, D
dc.contributor.authorStrohmaier, J
dc.contributor.authorAbdellaoui, A
dc.contributor.authorAdolfsson, R
dc.contributor.authorAir, TM
dc.contributor.authorAkil, H
dc.contributor.authorAlda, M
dc.contributor.authorAlliey-Rodriguez, N
dc.contributor.authorAndreassen, OA
dc.contributor.authorBabadjanova, G
dc.contributor.authorBass, NJ
dc.contributor.authorBauer, M
dc.contributor.authorBaune, BT
dc.contributor.authorBellivier, F
dc.contributor.authorBergen, S
dc.contributor.authorBethell, A
dc.contributor.authorBiernacka, JM
dc.contributor.authorBlackwood, DHR
dc.contributor.authorBoks, MP
dc.contributor.authorBoomsma, DI
dc.contributor.authorBørglum, AD
dc.contributor.authorBorrmann-Hassenbach, M
dc.contributor.authorBrennan, P
dc.contributor.authorBudde, M
dc.contributor.authorButtenschøn, HN
dc.contributor.authorByrne, EM
dc.contributor.authorCervantes, P
dc.contributor.authorClarke, T-K
dc.contributor.authorCraddock, N
dc.contributor.authorCruceanu, C
dc.contributor.authorCurtis, D
dc.contributor.authorCzerski, PM
dc.contributor.authorDannlowski, U
dc.contributor.authorDavis, T
dc.contributor.authorde Geus, EJC
dc.contributor.authorDi Florio, A
dc.contributor.authorDjurovic, S
dc.contributor.authorDomenici, E
dc.contributor.authorEdenberg, HJ
dc.contributor.authorEtain, B
dc.contributor.authorFischer, SB
dc.contributor.authorForty, L
dc.contributor.authorFraser, C
dc.contributor.authorFrye, MA
dc.contributor.authorFullerton, JM
dc.contributor.authorGade, K
dc.contributor.authorGershon, ES
dc.contributor.authorGiegling, I
dc.contributor.authorGordon, SD
dc.contributor.authorGordon-Smith, K
dc.contributor.authorGrabe, HJ
dc.contributor.authorGreen, Elaine
dc.contributor.authorGreenwood, TA
dc.contributor.authorGrigoroiu-Serbanescu, M
dc.contributor.authorGuzman-Parra, J
dc.contributor.authorHall, LS
dc.contributor.authorHamshere, M
dc.contributor.authorHauser, J
dc.contributor.authorHautzinger, M
dc.contributor.authorHeilbronner, U
dc.contributor.authorHerms, S
dc.contributor.authorHitturlingappa, S
dc.contributor.authorHoffmann, P
dc.contributor.authorHolmans, P
dc.contributor.authorHottenga, J-J
dc.contributor.authorJamain, S
dc.contributor.authorJones, I
dc.contributor.authorJones, LA
dc.contributor.authorJuréus, A
dc.contributor.authorKahn, RS
dc.contributor.authorKammerer-Ciernioch, J
dc.contributor.authorKirov, G
dc.contributor.authorKittel-Schneider, S
dc.contributor.authorKloiber, S
dc.contributor.authorKnott, SV
dc.contributor.authorKogevinas, M
dc.contributor.authorLandén, M
dc.contributor.authorLeber, M
dc.contributor.authorLeboyer, M
dc.contributor.authorLi, QS
dc.contributor.authorLissowska, J
dc.contributor.authorLucae, S
dc.contributor.authorMartin, NG
dc.contributor.authorMayoral-Cleries, F
dc.contributor.authorMcElroy, SL
dc.contributor.authorMcIntosh, AM
dc.contributor.authorMcKay, JD
dc.contributor.authorMcQuillin, A
dc.contributor.authorMedland, SE
dc.contributor.authorMiddeldorp, CM
dc.contributor.authorMilaneschi, Y
dc.contributor.authorMitchell, PB
dc.contributor.authorMontgomery, GW
dc.contributor.authorMorken, G
dc.contributor.authorMors, O
dc.contributor.authorMühleisen, TW
dc.contributor.authorMüller-Myhsok, B
dc.contributor.authorMyers, RM
dc.contributor.authorNievergelt, CM
dc.contributor.authorNurnberger, JI
dc.contributor.authorO'Donovan, MC
dc.contributor.authorLoohuis, LMO
dc.contributor.authorOphoff, R
dc.contributor.authorOruc, L
dc.contributor.authorOwen, MJ
dc.contributor.authorPaciga, SA
dc.contributor.authorPenninx, BWJH
dc.contributor.authorPerry, A
dc.contributor.authorPfennig, A
dc.contributor.authorPotash, JB
dc.contributor.authorPreisig, M
dc.contributor.authorReif, A
dc.contributor.authorRivas, F
dc.contributor.authorRouleau, GA
dc.contributor.authorSchofield, PR
dc.contributor.authorSchulze, TG
dc.contributor.authorSchwarz, M
dc.contributor.authorScott, L
dc.contributor.authorSinnamon, GCB
dc.contributor.authorStahl, EA
dc.contributor.authorStrauss, J
dc.contributor.authorTurecki, G
dc.contributor.authorVan der Auwera, S
dc.contributor.authorVedder, H
dc.contributor.authorVincent, JB
dc.contributor.authorWillemsen, G
dc.contributor.authorWitt, CC
dc.contributor.authorWray, NR
dc.contributor.authorXi, HS
dc.contributor.authorTadic, A
dc.contributor.authorDahmen, N
dc.contributor.authorSchott, BH
dc.contributor.authorCichon, S
dc.contributor.authorNöthen, MM
dc.contributor.authorRipke, S
dc.contributor.authorMobascher, A
dc.contributor.authorRujescu, D
dc.contributor.authorLieb, K
dc.contributor.authorRoepke, S
dc.contributor.authorSchmahl, C
dc.contributor.authorBohus, M
dc.contributor.authorRietschel, M
dc.date.accessioned2019-04-10T15:36:10Z
dc.date.issued2017-06-20
dc.identifier.issn2158-3188
dc.identifier.issn2158-3188
dc.identifier.otherARTN e1155
dc.identifier.urihttp://hdl.handle.net/10026.1/13689
dc.description.abstract

<jats:title>Abstract</jats:title><jats:p>Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case–control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD. GWAS, gene-based tests and gene-set analyses were performed in 998 BOR patients and 1545 controls. Linkage disequilibrium score regression was used to detect the genetic overlap between BOR and these disorders. Single marker analysis revealed no significant association after correction for multiple testing. Gene-based analysis yielded two significant genes:<jats:italic>DPYD</jats:italic>(<jats:italic>P</jats:italic>=4.42 × 10<jats:sup>−7</jats:sup>) and<jats:italic>PKP4</jats:italic>(<jats:italic>P</jats:italic>=8.67 × 10<jats:sup>−7</jats:sup>); and gene-set analysis yielded a significant finding for exocytosis (GO:0006887,<jats:italic>P</jats:italic><jats:sub>FDR</jats:sub>=0.019; FDR, false discovery rate). Prior studies have implicated<jats:italic>DPYD</jats:italic>,<jats:italic>PKP4</jats:italic>and exocytosis in BIP and SCZ. The most notable finding of the present study was the genetic overlap of BOR with BIP (<jats:italic>r</jats:italic><jats:sub>g</jats:sub>=0.28 [<jats:italic>P</jats:italic>=2.99 × 10<jats:sup>−3</jats:sup>]), SCZ (<jats:italic>r</jats:italic><jats:sub>g</jats:sub>=0.34 [<jats:italic>P</jats:italic>=4.37 × 10<jats:sup>−5</jats:sup>]) and MDD (<jats:italic>r</jats:italic><jats:sub>g</jats:sub>=0.57 [<jats:italic>P</jats:italic>=1.04 × 10<jats:sup>−3</jats:sup>]). We believe our study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined to transdiagnostic clinical symptoms should be examined in future studies.</jats:p>

dc.format.extente1155-e1155
dc.format.mediumElectronic
dc.languageen
dc.language.isoen
dc.publisherSpringer Nature [academic journals on nature.com]
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectBipolar Disorder
dc.subjectBorderline Personality Disorder
dc.subjectCase-Control Studies
dc.subjectDepressive Disorder, Major
dc.subjectFemale
dc.subjectGenetic Predisposition to Disease
dc.subjectGenome-Wide Association Study
dc.subjectGenotype
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMultifactorial Inheritance
dc.subjectSchizophrenia
dc.subjectYoung Adult
dc.titleGenome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia
dc.typejournal-article
dc.typeJournal Article
dc.typeResearch Support, Non-U.S. Gov't
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000403846500002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue6
plymouth.volume7
plymouth.publication-statusPublished online
plymouth.journalTranslational Psychiatry
dc.identifier.doi10.1038/tp.2017.115
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
plymouth.organisational-group/Plymouth/Users by role
dc.publisher.placeUnited States
dcterms.dateAccepted2017-04-10
dc.rights.embargodate2019-4-11
dc.identifier.eissn2158-3188
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1038/tp.2017.115
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-06-20
rioxxterms.typeJournal Article/Review


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