Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia
dc.contributor.author | Witt, SH | |
dc.contributor.author | Streit, F | |
dc.contributor.author | Jungkunz, M | |
dc.contributor.author | Frank, J | |
dc.contributor.author | Awasthi, S | |
dc.contributor.author | Reinbold, CS | |
dc.contributor.author | Treutlein, J | |
dc.contributor.author | Degenhardt, F | |
dc.contributor.author | Forstner, AJ | |
dc.contributor.author | Heilmann-Heimbach, S | |
dc.contributor.author | Dietl, L | |
dc.contributor.author | Schwarze, CE | |
dc.contributor.author | Schendel, D | |
dc.contributor.author | Strohmaier, J | |
dc.contributor.author | Abdellaoui, A | |
dc.contributor.author | Adolfsson, R | |
dc.contributor.author | Air, TM | |
dc.contributor.author | Akil, H | |
dc.contributor.author | Alda, M | |
dc.contributor.author | Alliey-Rodriguez, N | |
dc.contributor.author | Andreassen, OA | |
dc.contributor.author | Babadjanova, G | |
dc.contributor.author | Bass, NJ | |
dc.contributor.author | Bauer, M | |
dc.contributor.author | Baune, BT | |
dc.contributor.author | Bellivier, F | |
dc.contributor.author | Bergen, S | |
dc.contributor.author | Bethell, A | |
dc.contributor.author | Biernacka, JM | |
dc.contributor.author | Blackwood, DHR | |
dc.contributor.author | Boks, MP | |
dc.contributor.author | Boomsma, DI | |
dc.contributor.author | Børglum, AD | |
dc.contributor.author | Borrmann-Hassenbach, M | |
dc.contributor.author | Brennan, P | |
dc.contributor.author | Budde, M | |
dc.contributor.author | Buttenschøn, HN | |
dc.contributor.author | Byrne, EM | |
dc.contributor.author | Cervantes, P | |
dc.contributor.author | Clarke, T-K | |
dc.contributor.author | Craddock, N | |
dc.contributor.author | Cruceanu, C | |
dc.contributor.author | Curtis, D | |
dc.contributor.author | Czerski, PM | |
dc.contributor.author | Dannlowski, U | |
dc.contributor.author | Davis, T | |
dc.contributor.author | de Geus, EJC | |
dc.contributor.author | Di Florio, A | |
dc.contributor.author | Djurovic, S | |
dc.contributor.author | Domenici, E | |
dc.contributor.author | Edenberg, HJ | |
dc.contributor.author | Etain, B | |
dc.contributor.author | Fischer, SB | |
dc.contributor.author | Forty, L | |
dc.contributor.author | Fraser, C | |
dc.contributor.author | Frye, MA | |
dc.contributor.author | Fullerton, JM | |
dc.contributor.author | Gade, K | |
dc.contributor.author | Gershon, ES | |
dc.contributor.author | Giegling, I | |
dc.contributor.author | Gordon, SD | |
dc.contributor.author | Gordon-Smith, K | |
dc.contributor.author | Grabe, HJ | |
dc.contributor.author | Green, Elaine | |
dc.contributor.author | Greenwood, TA | |
dc.contributor.author | Grigoroiu-Serbanescu, M | |
dc.contributor.author | Guzman-Parra, J | |
dc.contributor.author | Hall, LS | |
dc.contributor.author | Hamshere, M | |
dc.contributor.author | Hauser, J | |
dc.contributor.author | Hautzinger, M | |
dc.contributor.author | Heilbronner, U | |
dc.contributor.author | Herms, S | |
dc.contributor.author | Hitturlingappa, S | |
dc.contributor.author | Hoffmann, P | |
dc.contributor.author | Holmans, P | |
dc.contributor.author | Hottenga, J-J | |
dc.contributor.author | Jamain, S | |
dc.contributor.author | Jones, I | |
dc.contributor.author | Jones, LA | |
dc.contributor.author | Juréus, A | |
dc.contributor.author | Kahn, RS | |
dc.contributor.author | Kammerer-Ciernioch, J | |
dc.contributor.author | Kirov, G | |
dc.contributor.author | Kittel-Schneider, S | |
dc.contributor.author | Kloiber, S | |
dc.contributor.author | Knott, SV | |
dc.contributor.author | Kogevinas, M | |
dc.contributor.author | Landén, M | |
dc.contributor.author | Leber, M | |
dc.contributor.author | Leboyer, M | |
dc.contributor.author | Li, QS | |
dc.contributor.author | Lissowska, J | |
dc.contributor.author | Lucae, S | |
dc.contributor.author | Martin, NG | |
dc.contributor.author | Mayoral-Cleries, F | |
dc.contributor.author | McElroy, SL | |
dc.contributor.author | McIntosh, AM | |
dc.contributor.author | McKay, JD | |
dc.contributor.author | McQuillin, A | |
dc.contributor.author | Medland, SE | |
dc.contributor.author | Middeldorp, CM | |
dc.contributor.author | Milaneschi, Y | |
dc.contributor.author | Mitchell, PB | |
dc.contributor.author | Montgomery, GW | |
dc.contributor.author | Morken, G | |
dc.contributor.author | Mors, O | |
dc.contributor.author | Mühleisen, TW | |
dc.contributor.author | Müller-Myhsok, B | |
dc.contributor.author | Myers, RM | |
dc.contributor.author | Nievergelt, CM | |
dc.contributor.author | Nurnberger, JI | |
dc.contributor.author | O'Donovan, MC | |
dc.contributor.author | Loohuis, LMO | |
dc.contributor.author | Ophoff, R | |
dc.contributor.author | Oruc, L | |
dc.contributor.author | Owen, MJ | |
dc.contributor.author | Paciga, SA | |
dc.contributor.author | Penninx, BWJH | |
dc.contributor.author | Perry, A | |
dc.contributor.author | Pfennig, A | |
dc.contributor.author | Potash, JB | |
dc.contributor.author | Preisig, M | |
dc.contributor.author | Reif, A | |
dc.contributor.author | Rivas, F | |
dc.contributor.author | Rouleau, GA | |
dc.contributor.author | Schofield, PR | |
dc.contributor.author | Schulze, TG | |
dc.contributor.author | Schwarz, M | |
dc.contributor.author | Scott, L | |
dc.contributor.author | Sinnamon, GCB | |
dc.contributor.author | Stahl, EA | |
dc.contributor.author | Strauss, J | |
dc.contributor.author | Turecki, G | |
dc.contributor.author | Van der Auwera, S | |
dc.contributor.author | Vedder, H | |
dc.contributor.author | Vincent, JB | |
dc.contributor.author | Willemsen, G | |
dc.contributor.author | Witt, CC | |
dc.contributor.author | Wray, NR | |
dc.contributor.author | Xi, HS | |
dc.contributor.author | Tadic, A | |
dc.contributor.author | Dahmen, N | |
dc.contributor.author | Schott, BH | |
dc.contributor.author | Cichon, S | |
dc.contributor.author | Nöthen, MM | |
dc.contributor.author | Ripke, S | |
dc.contributor.author | Mobascher, A | |
dc.contributor.author | Rujescu, D | |
dc.contributor.author | Lieb, K | |
dc.contributor.author | Roepke, S | |
dc.contributor.author | Schmahl, C | |
dc.contributor.author | Bohus, M | |
dc.contributor.author | Rietschel, M | |
dc.date.accessioned | 2019-04-10T15:36:10Z | |
dc.date.issued | 2017-06-20 | |
dc.identifier.issn | 2158-3188 | |
dc.identifier.issn | 2158-3188 | |
dc.identifier.other | ARTN e1155 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/13689 | |
dc.description.abstract |
<jats:title>Abstract</jats:title><jats:p>Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case–control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD. GWAS, gene-based tests and gene-set analyses were performed in 998 BOR patients and 1545 controls. Linkage disequilibrium score regression was used to detect the genetic overlap between BOR and these disorders. Single marker analysis revealed no significant association after correction for multiple testing. Gene-based analysis yielded two significant genes:<jats:italic>DPYD</jats:italic>(<jats:italic>P</jats:italic>=4.42 × 10<jats:sup>−7</jats:sup>) and<jats:italic>PKP4</jats:italic>(<jats:italic>P</jats:italic>=8.67 × 10<jats:sup>−7</jats:sup>); and gene-set analysis yielded a significant finding for exocytosis (GO:0006887,<jats:italic>P</jats:italic><jats:sub>FDR</jats:sub>=0.019; FDR, false discovery rate). Prior studies have implicated<jats:italic>DPYD</jats:italic>,<jats:italic>PKP4</jats:italic>and exocytosis in BIP and SCZ. The most notable finding of the present study was the genetic overlap of BOR with BIP (<jats:italic>r</jats:italic><jats:sub>g</jats:sub>=0.28 [<jats:italic>P</jats:italic>=2.99 × 10<jats:sup>−3</jats:sup>]), SCZ (<jats:italic>r</jats:italic><jats:sub>g</jats:sub>=0.34 [<jats:italic>P</jats:italic>=4.37 × 10<jats:sup>−5</jats:sup>]) and MDD (<jats:italic>r</jats:italic><jats:sub>g</jats:sub>=0.57 [<jats:italic>P</jats:italic>=1.04 × 10<jats:sup>−3</jats:sup>]). We believe our study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined to transdiagnostic clinical symptoms should be examined in future studies.</jats:p> | |
dc.format.extent | e1155-e1155 | |
dc.format.medium | Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Springer Nature [academic journals on nature.com] | |
dc.subject | Adolescent | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Bipolar Disorder | |
dc.subject | Borderline Personality Disorder | |
dc.subject | Case-Control Studies | |
dc.subject | Depressive Disorder, Major | |
dc.subject | Female | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Genotype | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Multifactorial Inheritance | |
dc.subject | Schizophrenia | |
dc.subject | Young Adult | |
dc.title | Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Research Support, Non-U.S. Gov't | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000403846500002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 6 | |
plymouth.volume | 7 | |
plymouth.publication-status | Published online | |
plymouth.journal | Translational Psychiatry | |
dc.identifier.doi | 10.1038/tp.2017.115 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2017-04-10 | |
dc.rights.embargodate | 2019-4-11 | |
dc.identifier.eissn | 2158-3188 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1038/tp.2017.115 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2017-06-20 | |
rioxxterms.type | Journal Article/Review |