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dc.contributor.authorSaxena, A
dc.contributor.authorJones, L
dc.contributor.authorShankar, R
dc.contributor.authorMcLean, B
dc.contributor.authorNewman, CGJ
dc.contributor.authorHamandi, K
dc.date.accessioned2019-01-10T12:39:39Z
dc.date.available2019-01-10T12:39:39Z
dc.date.issued2018-10
dc.identifier.issn0022-3050
dc.identifier.issn1468-330X
dc.identifier.urihttp://hdl.handle.net/10026.1/13119
dc.description.abstract

<jats:p>Sudden unexpected death in epilepsy (SUDEP) in children, although rare, needs critical attention given the tragic nature and devastating consequences for families and caregivers. True incidence is unknown and risk factors are not completely understood, more so in children compared with adults. A focused narrative review of available studies on paediatric SUDEP was undertaken to comprehend its risk factors and to develop strategies to recognise and where possible modify SUDEP risk and ultimately reduce incidence. We reviewed 16 population-based studies from various settings. We found overlapping risk factors from different studies. The prime risk factor is uncontrolled seizures. This review supports the view that children entering adolescence with optimal seizure control could be a key aspect in reducing adult mortality related to SUDEP. Ideally, clinicians would want to be able to predict prospective, individualised SUDEP risk, which is challenging due to a myriad of risk factors and an inherent non-homogeneous paediatric epilepsy population. Nevertheless, an adequate evidence base exists as evidenced by this review to support information giving and communication to support young people with epilepsy and their families in being active partners in recognising and reducing their SUDEP risk. More work particularly in the form of prospective studies and registries are needed to further clarify true incidence which may have been previously underestimated and to update risk factors.</jats:p>

dc.format.extentjnnp-2017-317702-jnnp-2017-317702
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoen
dc.publisherBMJ Publishing Group
dc.rightsAttribution-NonCommercial 4.0 International
dc.rightsAttribution-NonCommercial 4.0 International
dc.rightsAttribution-NonCommercial 4.0 International
dc.rightsAttribution-NonCommercial 4.0 International
dc.rightsAttribution-NonCommercial 4.0 International
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectepilepsy
dc.subjectnon-clinician
dc.subjectpaediatric neurology
dc.subjectpost mortem
dc.subjectsudden death
dc.subjectAdolescent
dc.subjectChild
dc.subjectDeath, Sudden
dc.subjectEpilepsy
dc.subjectHumans
dc.subjectIncidence
dc.subjectRisk Factors
dc.subjectSeizures
dc.titleSudden unexpected death in epilepsy in children: a focused review of incidence and risk factors
dc.typejournal-article
dc.typeReview
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/29632029
plymouth.issue10
plymouth.volume89
plymouth.publisher-urlhttp://dx.doi.org/10.1136/jnnp-2017-317702
plymouth.publication-statusPublished
plymouth.journalJournal of Neurology, Neurosurgery and Psychiatry
dc.identifier.doi10.1136/jnnp-2017-317702
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CCT&PS
plymouth.organisational-group/Plymouth/Users by role
dc.publisher.placeEngland
dcterms.dateAccepted2018-03-12
dc.identifier.eissn1468-330X
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1136/jnnp-2017-317702
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/
rioxxterms.licenseref.startdate2018-10
rioxxterms.typeJournal Article/Review


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