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dc.contributor.authorJones, Len
dc.contributor.authorShankar, Ren
dc.contributor.authorMcLean, Ben
dc.contributor.authorNewman, CGJen
dc.contributor.authorHamandi, Ken
dc.date.accessioned2019-01-10T12:39:39Z
dc.date.available2019-01-10T12:39:39Z
dc.date.issued2018-10-01en
dc.identifier.issn0022-3050en
dc.identifier.urihttp://hdl.handle.net/10026.1/13119
dc.description.abstract

© 2018 Article author(s) (or their employer(s) unless otherwise stated in the text of the article). all rights reserved. Sudden unexpected death in epilepsy (SUDEP) in children, although rare, needs critical attention given the tragic nature and devastating consequences for families and caregivers. True incidence is unknown and risk factors are not completely understood, more so in children compared with adults. A focused narrative review of available studies on paediatric SUDEP was undertaken to comprehend its risk factors and to develop strategies to recognise and where possible modify SUDEP risk and ultimately reduce incidence. We reviewed 16 population-based studies from various settings. We found overlapping risk factors from different studies. The prime risk factor is uncontrolled seizures. This review supports the view that children entering adolescence with optimal seizure control could be a key aspect in reducing adult mortality related to SUDEP. Ideally, clinicians would want to be able to predict prospective, individualised SUDEP risk, which is challenging due to a myriad of risk factors and an inherent non-homogeneous paediatric epilepsy population. Nevertheless, an adequate evidence base exists as evidenced by this review to support information giving and communication to support young people with epilepsy and their families in being active partners in recognising and reducing their SUDEP risk. More work particularly in the form of prospective studies and registries are needed to further clarify true incidence which may have been previously underestimated and to update risk factors.

en
dc.format.extent1064 - 1070en
dc.language.isoenen
dc.titleSudden unexpected death in epilepsy in children: A focused review of incidence and risk factorsen
dc.typeJournal Article
plymouth.issue10en
plymouth.volume89en
plymouth.publication-statusPublisheden
plymouth.journalJournal of Neurology, Neurosurgery and Psychiatryen
dc.identifier.doi10.1136/jnnp-2017-317702en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Centre for Clinical Trials & Health Research
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Centre for Clinical Trials & Health Research/RC reporting group CTPS
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Collaboration for the Advancement of Medical Education Research Assessment
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CCT&PS
dc.identifier.eissn1468-330Xen
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1136/jnnp-2017-317702en
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/en
rioxxterms.typeJournal Article/Reviewen


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