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dc.contributor.authorSinger, Den
dc.contributor.authorThamm, Ken
dc.contributor.authorZhuang, Hen
dc.contributor.authorKarbanová, Jen
dc.contributor.authorGao, Yen
dc.contributor.authorWalker, JVen
dc.contributor.authorJin, Hen
dc.contributor.authorWu, Xen
dc.contributor.authorCoveney, CRen
dc.contributor.authorMarangoni, Pen
dc.contributor.authorLu, Den
dc.contributor.authorGrayson, PRCen
dc.contributor.authorGulsen, Ten
dc.contributor.authorLiu, KJen
dc.contributor.authorArdu, Sen
dc.contributor.authorWann, AKen
dc.contributor.authorLuo, Sen
dc.contributor.authorZambon, ACen
dc.contributor.authorJetten, AMen
dc.contributor.authorTredwin, Cen
dc.contributor.authorKlein, ODen
dc.contributor.authorAttanasio, Men
dc.contributor.authorCarmeliet, Pen
dc.contributor.authorHuttner, WBen
dc.contributor.authorCorbeil, Den
dc.contributor.authorHu, Ben
dc.date.accessioned2018-12-21T21:22:10Z
dc.date.issued2018-12-06en
dc.identifier.issn0261-4189en
dc.identifier.urihttp://hdl.handle.net/10026.1/13101
dc.description.abstract

Proper temporal and spatial activation of stem cells relies on highly coordinated cell signaling. The primary cilium is the sensory organelle that is responsible for transmitting extracellular signals into a cell. Primary cilium size, architecture, and assembly-disassembly dynamics are under rigid cell cycle-dependent control. Using mouse incisor tooth epithelia as a model, we show that ciliary dynamics in stem cells require the proper functions of a cholesterol-binding membrane glycoprotein, Prominin-1 (Prom1/CD133), which controls sequential recruitment of ciliary membrane components, histone deacetylase, and transcription factors. Nuclear translocation of Prom1 and these molecules is particularly evident in transit amplifying cells, the immediate derivatives of stem cells. The absence of Prom1 impairs ciliary dynamics and abolishes the growth stimulation effects of sonic hedgehog (SHH) treatment, resulting in the disruption of stem cell quiescence maintenance and activation. We propose that Prom1 is a key regulator ensuring appropriate response of stem cells to extracellular signals, with important implications for development, regeneration, and diseases.

en
dc.language.isoenen
dc.publisherEMBO Pressen
dc.subjectCD133en
dc.subjectciliaen
dc.subjectsonic hedgehogen
dc.subjectstem cellsen
dc.subjecttoothen
dc.titleProminin-1 controls stem cell activation by orchestrating ciliary dynamics.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/30523147en
plymouth.journalEMBO Journalen
dc.identifier.doi10.15252/embj.201899845en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Biomedical Research Group
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Biomedical Research Group/RC Reporting Group BRG
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Collaboration for the Advancement of Medical Education Research Assessment
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Neuroscience
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Peninsula Dental School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
dcterms.dateAccepted2018-10-23en
dc.rights.embargodate2019-01-04en
dc.identifier.eissn1460-2075en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.15252/embj.201899845en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-12-06en
rioxxterms.typeJournal Article/Reviewen
plymouth.funderRole of the FoxN1 gene as a central regulator of epidermal planar cell polarity signaling expression and function::BBSRCen
plymouth.funderRole of the FoxN1 gene as a central regulator of epidermal planar cell polarity signaling expression and function::BBSRCen


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