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dc.contributor.authorSinger, D
dc.contributor.authorThamm, K
dc.contributor.authorZhuang, H
dc.contributor.authorKarbanová, J
dc.contributor.authorGao, Y
dc.contributor.authorWalker, JV
dc.contributor.authorJin, H
dc.contributor.authorWu, X
dc.contributor.authorCoveney, CR
dc.contributor.authorMarangoni, P
dc.contributor.authorLu, D
dc.contributor.authorGrayson, PRC
dc.contributor.authorGulsen, T
dc.contributor.authorLiu, KJ
dc.contributor.authorArdu, S
dc.contributor.authorWann, AK
dc.contributor.authorLuo, Shouqing
dc.contributor.authorZambon, AC
dc.contributor.authorJetten, AM
dc.contributor.authorTredwin, Christopher
dc.contributor.authorKlein, OD
dc.contributor.authorAttanasio, M
dc.contributor.authorCarmeliet, P
dc.contributor.authorHuttner, WB
dc.contributor.authorCorbeil, D
dc.contributor.authorHu, Bing
dc.date.accessioned2018-12-21T21:22:10Z
dc.date.issued2018-12-06
dc.identifier.issn0261-4189
dc.identifier.issn1460-2075
dc.identifier.othere99845
dc.identifier.urihttp://hdl.handle.net/10026.1/13101
dc.description.abstract

Proper temporal and spatial activation of stem cells relies on highly coordinated cell signaling. The primary cilium is the sensory organelle that is responsible for transmitting extracellular signals into a cell. Primary cilium size, architecture, and assembly-disassembly dynamics are under rigid cell cycle-dependent control. Using mouse incisor tooth epithelia as a model, we show that ciliary dynamics in stem cells require the proper functions of a cholesterol-binding membrane glycoprotein, Prominin-1 (Prom1/CD133), which controls sequential recruitment of ciliary membrane components, histone deacetylase, and transcription factors. Nuclear translocation of Prom1 and these molecules is particularly evident in transit amplifying cells, the immediate derivatives of stem cells. The absence of Prom1 impairs ciliary dynamics and abolishes the growth stimulation effects of sonic hedgehog (SHH) treatment, resulting in the disruption of stem cell quiescence maintenance and activation. We propose that Prom1 is a key regulator ensuring appropriate response of stem cells to extracellular signals, with important implications for development, regeneration, and diseases.

dc.format.extent0-0
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoen
dc.publisherEMBO Press
dc.subjectCD133
dc.subjectcilia
dc.subjectsonic hedgehog
dc.subjectstem cells
dc.subjecttooth
dc.titleProminin-1 controls stem cell activation by orchestrating ciliary dynamics
dc.typejournal-article
dc.typeJournal Article
dc.typeResearch Support, N.I.H., Extramural
dc.typeResearch Support, Non-U.S. Gov't
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/30523147
plymouth.issue2
plymouth.volume38
plymouth.publication-statusPublished
plymouth.journalEMBO Journal
dc.identifier.doi10.15252/embj.201899845
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Dental School
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
plymouth.organisational-group/Plymouth/Users by role/Researchers in ResearchFish submission
dc.publisher.placeEngland
dcterms.dateAccepted2018-10-23
dc.rights.embargodate2019-1-4
dc.identifier.eissn1460-2075
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.15252/embj.201899845
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-12-06
rioxxterms.typeJournal Article/Review
plymouth.funderRole of the FoxN1 gene as a central regulator of epidermal planar cell polarity signaling expression and function::BBSRC
plymouth.funderRole of the FoxN1 gene as a central regulator of epidermal planar cell polarity signaling expression and function::BBSRC


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