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Investigation into Inter-alpha Trypsin Inhibitor Heavy Chain 4 (ITIH4) as a biomarker for prenatal screening of Down syndrome using maternal plasma samples
(University of Plymouth, 2011)
Background: Down Syndrome (DS) effects 3 per 1000 births and is a significant cause of fetal loss. Currently screening tests detect ~85% of affected pregnancies, with a 5% false-positive rate, whilst diagnosis requires ...